Details of the Drug

General Information of Drug (ID: DM1YAK6)

Drug Name
GDC0941
Synonyms
Pictilisib; GDC-0941; 957054-30-7; PICTILISIB; Pictrelisib; GDC 0941; 4-(2-(1H-Indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine; 2-(1H-Indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine; UNII-ICY00EMP8P; ICY00EMP8P; Pictilisib (GDC-0941); CHEBI:65326; AK-40872; Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-; GD9; GDC-0941, GDC0941; 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 2 [1]
Non-hodgkin lymphoma 2B33.5 Phase 2 [2]
Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 513.6
Logarithm of the Partition Coefficient (xlogp) 1.6
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 10
Chemical Identifiers
Formula
C23H27N7O3S2
IUPAC Name
4-[2-(1H-indazol-4-yl)-6-[(4-methylsulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine
Canonical SMILES
CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6
InChI
InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27)
InChIKey
LHNIIDJUOCFXAP-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
17755052
ChEBI ID
CHEBI:65326
CAS Number
957054-30-7
UNII
ICY00EMP8P
DrugBank ID
DB11663
TTD ID
D08QGT
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PI3-kinase gamma (PIK3CG) TTHBTOP PK3CG_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [4]
Atos homolog protein A (ATOSA) OTWFM5G0 ATOSA_HUMAN Gene/Protein Processing [5]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Regulation of Drug Effects [6]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Gene/Protein Processing [7]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Post-Translational Modifications [8]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [9]
Carbonic anhydrase 9 (CA9) OTNA51XT CAH9_HUMAN Gene/Protein Processing [10]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [11]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [12]
Cathepsin B (CTSB) OTP9G5QB CATB_HUMAN Gene/Protein Processing [13]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Breast cancer
ICD Disease Classification 2C60-2C65
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
PI3-kinase gamma (PIK3CG) DTT PIK3CG 1.98E-01 -0.05 -0.55
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1; GDSC2 2.3192 7.2756 0.4579 18.5758
HuO9 GDSC1; GDSC2 -1.0759 5.1273 -2.0683 41.6544
EW-12 GDSC2 -1.0142 3.1018 -1.6447 33.2216
ES5 GDSC1; GDSC2 -0.9688 4.7259 -2.2448 35.2821
SK-ES-1 GDSC1; GDSC2; CTRP2 -0.6856 5.1083 -1.0674 45.4096
EW-18 GDSC1; GDSC2 -0.5053 5.734 -1.6936 37.9632
EW-7 GDSC1; GDSC2 -0.3252 3.4592 -0.6966 33.8672
ES1 GDSC1; GDSC2 -0.2856 4.0606 -0.839 34.2273
ES8 GDSC1; GDSC2 -0.0733 5.2139 -1.0293 33.946
CHSA0108 GDSC1; GDSC2 -0.0112 5.2847 -1.5176 28.0275
NOS-1 [Human HNSCC] GDSC1; GDSC2 0.0345 5.4772 -1.0197 33.4372
EW-3 GDSC1; GDSC2 0.1746 4.7285 -0.5784 31.1635
EW-11 GDSC1; GDSC2 0.3472 5.8089 -0.8279 31.4065
CHSA8926 GDSC1; GDSC2 0.3705 6.8656 -1.2616 32.848
SaOS-2 GDSC1; GDSC2; CTRP2 0.5176 7.4934 -0.437 39.1975
EW-22 GDSC1; GDSC2 0.7075 5.1796 -0.1891 27.3166
ES7 GDSC1; GDSC2 0.847 7.03 -0.8535 29.5162
SK-N-MC CTRP2 1.0239 5.0393 0.8034 34.1525
G-292 clone A141B1 GDSC1; GDSC2; CTRP2 1.0339 6.8935 0.3229 35.4932
EW-1 GDSC1; GDSC2 1.1383 5.316 0.2044 23.8464
ES4 GDSC1; GDSC2 1.3449 5.9257 0.1489 23.3526
MHH-ES-1 GDSC1; GDSC2; CTRP2 1.539 6.8668 0.8807 32.146
CHSA0011 GDSC1; GDSC2 1.6084 6.5704 -0.6192 17.4336
TC-71 GDSC1; GDSC2 1.613 7.3837 -0.2638 24.311
MG-63 GDSC1; GDSC2; CTRP2 1.6287 8.2612 0.4799 33.0141
HuO-3N1 GDSC1; GDSC2 1.8462 8.3412 -0.5033 24.5674
ES6 GDSC1; GDSC2 1.948 8.3804 -0.4272 23.9093
SK-PN-DW GDSC1; GDSC2 1.9741 5.9801 0.7519 18.1771
EW-16 GDSC1; GDSC2 1.9766 9.7258 -1.0603 26.3721
A-673 GDSC1; GDSC2; CTRP2 2.0393 5.807 1.7359 27.7191
EW-24 GDSC1; GDSC2 2.0563 5.8031 0.9156 17.0536
U-CH2 GDSC2 2.2603 4.7242 0.8483 6.5684
H-EMC-SS GDSC1; GDSC2 2.2724 7.7993 0.158 20.2007
TC71 CTRP2 2.2954 6.1989 1.9098 26.3097
EW-13 GDSC1; GDSC2 2.5035 9.9682 -0.7057 23.356
SJSA-1 GDSC1; GDSC2; CTRP2 2.6324 8.5844 1.4147 26.992
CAL-72 GDSC1; GDSC2 3.5392 10.164 0.0802 16.9889
U2OS GDSC1; GDSC2; CTRP2 3.7965 10.5293 1.7339 22.667
CADO-ES1 GDSC1; GDSC2 3.8867 7.9953 1.4376 9.1403
Hs 888.T CTRP2 3.9921 13.9122 0.292 26.7967
SW1353 CTRP2 4.4705 9.0896 3.0709 15.8862
NY GDSC1; GDSC2 5.2633 13.4548 -0.2318 14.4649
HOS GDSC1; GDSC2; CTRP2 5.4701 13.2494 1.9527 17.9439
CAL-78 GDSC1; GDSC2; CTRP2 5.4993 12.9454 2.1297 17.224
Hs 822.T CTRP2 10.8373 24.1165 0.6227 13.5366
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 219 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 1.2948 8.0462 0.2037 34.8847
JK1 CTRP2 2.9694 6.1934 2.6467 21.6171
JM1 GDSC1; GDSC2; CTRP2 2.6387 8.4037 1.4954 26.7006
Ri-1 CTRP2 -6.8288 2.524 -7.2236 73.6864
SU-DHL-6 GDSC1; GDSC2; CTRP2 -4.6368 -1.4064 -4.6389 70.6641
WSU-NHL GDSC1; GDSC2 -4.0225 -0.4039 -4.0601 63.9631
OCI-Ly7 GDSC1; GDSC2 -3.9657 -1.8299 -3.9699 59.7297
NCI-H929 GDSC1; GDSC2; CTRP2 -3.4383 -0.3479 -3.4416 63.0038
SU-DHL-5 GDSC1; GDSC2 -3.2725 -1.0016 -3.276 58.3436
Kasumi-2 CTRP2 -2.9971 8.8062 -4.6945 56.1501
HAL-01 GDSC1; GDSC2 -2.7193 3.3123 -3.2685 52.7226
KMS-34 CTRP2 -2.6985 0.4779 -2.7053 58.1439
RCH-ACV GDSC1; GDSC2; CTRP2 -2.526 3.6407 -2.7791 56.1636
Farage GDSC1; GDSC2 -2.368 1.4092 -2.6196 44.4891
BONNA-12 GDSC2 -2.2638 3.0423 -2.9745 44.4301
MOLM-16 GDSC1; GDSC2; CTRP2 -1.9507 3.1667 -2.0964 53.0124
SU-DHL-16 GDSC1; GDSC2 -1.8315 0.0123 -1.8488 38.5308
NALM-6 GDSC1; GDSC2; CTRP2 -1.6043 4.4614 -1.9301 50.8385
PL-21 GDSC1; GDSC2 -1.5932 3.017 -2.2396 38.5632
MM1.S GDSC1; GDSC2; CTRP2 -1.5224 1.5011 -1.5337 50.4079
GA-10 GDSC1; GDSC2; CTRP2 -1.489 4.0784 -1.7358 50.1701
KMS-26 CTRP2 -1.4659 -0.5834 -1.4659 50.0344
Karpas-1106P GDSC1; GDSC2 -1.4459 2.8738 -1.7662 43.0976
SKM-1 GDSC1; GDSC2 -1.4092 3.595 -2.2518 37.5781
BL-70 CTRP2 -1.3732 0.4452 -1.3734 49.4174
HH [Human lymphoma] GDSC1; GDSC2; CTRP2 -1.3696 13.5783 -4.8689 49.6956
MV4-11 GDSC1; GDSC2; CTRP2 -1.2975 5.1089 -1.7333 49.0666
Pfeiffer CTRP2 -1.2964 4.1138 -1.5344 49.0049
KMS-20 CTRP2 -1.2602 5.4819 -1.781 48.8773
Kasumi-1 GDSC1; GDSC2; CTRP2 -1.2561 3.1546 -1.3592 48.7005
WSU-DLCL2 GDSC1; GDSC2; CTRP2 -1.2463 0.7453 -1.2469 48.5727
PL21 CTRP2 -1.1982 4.3666 -1.4729 48.423
A4/Fukuda GDSC1; GDSC2; CTRP2 -1.0532 4.5776 -1.3559 47.5617
JVM-2 GDSC1; GDSC2; CTRP2 -1.0145 7.7092 -2.4479 45.2332
RPMI-8402 GDSC1; GDSC2; CTRP2 -0.8544 2.9948 -0.9213 46.0725
697 GDSC1; GDSC2; CTRP2 -0.8536 5.8246 -1.4247 46.59
NU-DUL-1 GDSC1; GDSC2; CTRP2 -0.7927 4.7287 -1.1035 45.9816
MOLP-8 GDSC1; GDSC2; CTRP2 -0.6774 3.3054 -0.7642 44.9502
KHM-1B CTRP2 -0.6457 3.4328 -0.7441 44.7634
RPMI-8866 GDSC1; GDSC2 -0.624 5.1583 -2.0784 33.0508
ATN-1 GDSC1; GDSC2 -0.5224 5.1684 -1.4907 37.4871
KMS-12-BM GDSC2; CTRP2 -0.5187 4.5597 -0.7742 44.2058
NU-DHL-1 CTRP2 -0.4173 6.5382 -1.1483 44.2529
Hs 611.T CTRP2 -0.3993 8.4813 -1.7768 44.8528
GR-ST GDSC1; GDSC2 -0.2593 5.2251 -1.2317 35.4668
Reh GDSC1; GDSC2; CTRP2 -0.1961 5.0149 -0.515 42.2863
RS4;11 GDSC1; GDSC2; CTRP2 -0.1535 9.286 -2.1632 41.3953
SU-DHL-10 GDSC1; GDSC2; CTRP2 -0.1162 2.5104 -0.1299 41.0835
KMS-11 GDSC1; GDSC2; CTRP2 -0.0775 7.0553 -0.9377 42.4836
ARH-77 GDSC1; GDSC2 -0.0684 5.9282 -1.3124 34.8677
P30/OHK GDSC1; GDSC2 -0.0677 6.6524 -1.6183 35.7867
HT GDSC1; GDSC2; CTRP2 -0.0297 4.6231 -0.2575 41.0396
Karpas-422 GDSC1; GDSC2; CTRP2 0.0209 6.0549 -0.5321 41.3834
SUP-T11 CTRP2 0.0349 5.1665 -0.2967 40.8535
MOLM-13 GDSC1; GDSC2; CTRP2 0.0877 3.46 0.0257 39.8649
KY821 GDSC1; GDSC2 0.0953 5.7946 -1.0854 33.4027
MC116 GDSC1; GDSC2; CTRP2 0.0961 2.6492 0.0823 39.6713
CTB-1 GDSC1; GDSC2 0.1468 7.0555 -2.2 30.2156
CRO-AP2 GDSC1; GDSC2 0.1714 3.763 -0.6505 22.8745
Mono-Mac-1 CTRP2 0.2008 7.3594 -0.735 41.0067
L-363 GDSC1; GDSC2; CTRP2 0.228 4.4986 0.0422 39.2697
NK-92MI GDSC2 0.2892 6.786 -1.9345 28.6098
SU-DHL-4 GDSC1; GDSC2; CTRP2 0.2992 3.7382 0.2215 38.5093
TUR GDSC1; GDSC2 0.3351 5.6152 -0.7597 31.1974
GDM-1 GDSC1; GDSC2; CTRP2 0.3989 6.0269 -0.1119 38.9619
OCI-AML-3 GDSC1; GDSC2; CTRP2 0.4453 4.7057 0.2404 37.9022
AML-193 CTRP2 0.4615 4.528 0.2885 37.7084
Karpas-45 GDSC1; GDSC2 0.4741 5.1662 -0.4299 29.2963
MY-M12 GDSC1; GDSC2 0.4783 5.9583 -1.3561 25.2966
MLMA GDSC1; GDSC2 0.4857 8.591 -1.9342 34.4255
P32/ISH GDSC1; GDSC2 0.495 5.2768 -0.4526 29.3057
NOMO-1 GDSC1; GDSC2; CTRP2 0.5368 7.4145 -0.3892 39.026
BL-41 GDSC1; GDSC2 0.5948 3.7758 0.2104 25.9425
MHH-PREB-1 GDSC1; GDSC2 0.6849 5.0414 -0.157 27.2633
Ramos.2G6.4C10 GDSC1; GDSC2 0.7017 7.2563 -1.1026 30.9896
MHH-CALL-4 GDSC2; CTRP2 0.7165 5.7868 0.2982 36.722
EoL-1 GDSC1; GDSC2; CTRP2 0.7527 5.2493 0.4654 36.127
KMS-28BM CTRP2 0.7788 6.0963 0.2837 36.5287
DoHH2 GDSC1; GDSC2; CTRP2 0.7858 3.412 0.7568 35.1286
THP-1 GDSC1; GDSC2; CTRP2 0.7997 5.3951 0.484 35.9022
P3HR-1 CTRP2 0.8231 6.8487 0.1079 36.8149
ML-2 GDSC1; GDSC2 0.8376 5.4999 -0.1864 26.7945
Mono-Mac-6 GDSC1; GDSC2; CTRP2 0.8422 9.5368 -0.8591 38.8063
Jiyoye GDSC1; GDSC2 0.8562 5.1015 -0.0008 25.8827
SUP-B8 GDSC1; GDSC2 0.9014 16.8459 -6.3572 37.3888
VAL GDSC1; GDSC2 0.9154 8.7365 -1.5824 31.7883
NKM-1 GDSC1; GDSC2 0.9203 10.7116 -2.5253 34.3817
OCI-AML-5 GDSC1; GDSC2; CTRP2 0.9332 5.783 0.5355 35.2708
Ki-JK CTRP2 0.944 3.9134 0.8833 34.178
Daudi GDSC1; GDSC2; CTRP2 0.9521 4.042 0.8788 34.1648
Namalwa GDSC1; GDSC2; CTRP2 0.9549 5.7855 0.5586 35.1268
HuT 78 CTRP2 0.9897 7.5021 0.071 36.2967
PF-382 GDSC1; GDSC2; CTRP2 1.0332 6.2535 0.5171 34.9641
MOLT-4 GDSC1; GDSC2 1.0398 5.5198 0.015 25.1064
BC-1 GDSC1; GDSC2 1.0439 4.9649 0.2526 23.9727
YT GDSC1; GDSC2 1.0686 6.9501 -0.5952 27.6635
MOLT-3 CTRP2 1.135 4.5228 1.0123 33.1094
U-698-M GDSC1; GDSC2 1.1458 5.6554 0.0655 24.475
RPMI-8226 GDSC1; GDSC2; CTRP2 1.1564 5.6253 0.8183 33.6444
TALL-1 [Human adult T-ALL] GDSC2; CTRP2 1.1598 7.5027 0.2547 35.2243
LP-1 GDSC1; GDSC2; CTRP2 1.2814 4.3796 1.1883 32.0405
HL-60 GDSC1; GDSC2; CTRP2 1.3104 7.1075 0.553 33.8878
KMS-18 CTRP2 1.3201 4.3817 1.2292 31.776
AMO1 GDSC1; GDSC2; CTRP2 1.3321 7.3152 0.5061 33.9445
KMS-21-BM CTRP2 1.3502 4.8185 1.1966 31.7821
EHEB GDSC1; CTRP2 1.3626 10.6967 -0.8016 36.9232
RPMI-6666 GDSC1; GDSC2; CTRP2 1.3813 9.086 -0.1077 35.3581
SUP-T1 GDSC1; GDSC2; CTRP2 1.3946 7.192 0.6159 33.4192
ALL-PO GDSC1; GDSC2 1.434 7.6046 -0.5421 26.1289
NB4 GDSC1; GDSC2; CTRP2 1.4684 7.8112 0.4769 33.5597
M-07e CTRP2 1.4976 8.4292 0.2752 34.0065
OPM-2 GDSC1; GDSC2; CTRP2 1.5001 3.0471 1.4979 30.2821
KE-97 CTRP2 1.5158 7.5086 0.6371 32.9467
L-1236 GDSC1; GDSC2; CTRP2 1.5428 9.0535 0.0759 34.3678
BALL-1 GDSC1; GDSC2 1.5491 7.6695 -0.4618 25.3908
JVM-3 GDSC1; GDSC2; CTRP2 1.5728 9.7347 -0.1734 34.8751
F-36P CTRP2 1.5903 6.0445 1.1834 31.0233
Mino CTRP2 1.6106 6.9822 0.9206 31.7846
SR GDSC1; GDSC2; CTRP2 1.6475 6.6835 1.0574 31.2365
MOLT-16 GDSC1; GDSC2; CTRP2 1.6938 4.9872 1.5377 29.5096
Loucy GDSC1; GDSC2 1.6944 4.7941 1.0043 17.8334
Karpas-620 GDSC1; GDSC2; CTRP2 1.7395 9.1948 0.2255 33.3371
MHH-CALL-3 CTRP2 1.7443 12.0384 -1.0063 36.1138
WIL2 NS GDSC1; GDSC2 1.798 5.3433 0.8696 18.1642
QIMR-WIL GDSC1; GDSC2 1.8354 8.8037 -1.54 21.4807
EB1 CTRP2 1.8378 8.2587 0.7038 31.6898
CA46 GDSC1; GDSC2; CTRP2 1.8963 7.74 0.963 30.7196
ALL-SIL GDSC1; GDSC2 1.9323 8.3129 -0.4089 23.8811
SET-2 CTRP2 1.9364 4.2747 1.8925 27.5154
JJN-3 GDSC1; GDSC2; CTRP2 1.9468 6.0651 1.5669 28.5912
Jurkat GDSC1; GDSC2; CTRP2 1.9704 5.3799 1.5924 23.3626
KMOE-2 GDSC1; GDSC2 1.9882 7.5593 0.01 21.8085
DND-41 GDSC1; GDSC2; CTRP2 2.0702 6.297 1.6357 27.9646
OCI-Ly10 CTRP2 2.1088 8.2916 0.9794 29.9942
U-937 CTRP2 2.1285 4.6642 2.0534 26.3419
SUP-HD1 GDSC1; GDSC2; CTRP2 2.1365 6.4328 1.6676 27.6458
SEM CTRP2 2.1478 6.2401 1.7369 27.3722
SU-DHL-1 GDSC2; CTRP2 2.1567 6.3633 1.7104 27.4351
SUP-M2 GDSC1; GDSC2; CTRP2 2.2087 4.0378 2.1922 25.6092
CCRF-CEM GDSC1; GDSC2 2.2098 5.9067 1.0163 16.0234
ME1 CTRP2 2.2978 6.2259 1.9046 26.3203
EM-2 GDSC1; GDSC2; CTRP2 2.3129 7.9799 1.3181 28.2755
BC-3 GDSC2 2.3185 4.0998 1.2022 4.1972
BV-173 GDSC1; GDSC2; CTRP2 2.468 9.5648 0.8292 29.355
JSC-1 GDSC1; GDSC2 2.4833 5.8424 1.3091 13.5924
SIG-M5 GDSC2; CTRP2 2.4856 7.0773 1.8365 25.9807
KE-37 GDSC1; GDSC2; CTRP2 2.5149 4.9392 2.4283 23.808
HC-1 GDSC1; GDSC2 2.5755 9.1296 -0.2253 21.071
P31/FUJ GDSC1; GDSC2; CTRP2 2.7019 6.4417 2.2808 23.7454
CESS GDSC1; GDSC2 2.7042 7.9724 0.4638 17.3899
RL GDSC1; GDSC2; CTRP2 2.7047 7.3511 1.9748 24.833
HPB-ALL CTRP2 2.7117 6.6024 2.2409 23.859
CMK GDSC1; CTRP2 2.7195 6.8464 2.169 24.0937
Karpas-299 GDSC1; GDSC2; CTRP2 2.7267 5.0514 2.6385 22.4025
KCL-22 GDSC1; GDSC2; CTRP2 2.7505 7.4022 2.0052 24.5888
EB2 GDSC1; GDSC2 2.8116 8.0965 0.4971 16.9112
OCI-AML-2 GDSC1; GDSC2; CTRP2 2.8579 6.6636 2.38 22.918
MHH-CALL-2 GDSC1; GDSC2 2.874 6.7394 1.2269 12.8807
DB GDSC1; GDSC2; CTRP2 2.8869 6.7766 2.374 22.8528
RC-K8 GDSC1; GDSC2 2.9536 6.031 1.6494 10.3349
ST486 GDSC1; GDSC2; CTRP2 2.9752 6.1081 2.6772 21.4896
IM-9 GDSC1; GDSC2 2.9785 5.8534 1.7597 9.6535
CTV-1 GDSC1; GDSC2 3.0149 9.7211 -0.137 19.4073
DEL GDSC1; GDSC2; CTRP2 3.0179 6.3142 2.664 21.4078
EJM GDSC1; GDSC2; CTRP2 3.0334 8.8498 1.7218 24.7757
Sc-1 GDSC1 3.1545 4.7323 1.4337 1.6392
MN-60 GDSC1; GDSC2 3.1714 9.1035 0.3048 16.8726
SU-DHL-8 GDSC1; GDSC2; CTRP2 3.1754 6.1204 2.8923 20.1053
P12-Ichikawa GDSC1; GDSC2; CTRP2 3.2185 7.2938 2.5476 21.2451
NCO2 CTRP2 3.2562 6.1377 2.9756 19.5593
KM-H2 GDSC1; GDSC2; CTRP2 3.2824 9.8549 1.0492 21.6479
VL51 GDSC1; GDSC2 3.3218 10.9207 -0.4776 20.0889
JURL-MK1 GDSC1; GDSC2; CTRP2 3.3333 7.2171 2.6993 20.3507
KOPN-8 GDSC1; GDSC2 3.3356 10.0756 -0.0435 18.1028
Raji GDSC1; GDSC2; CTRP2 3.3594 7.7142 2.5347 20.8926
OCI-Ly19 GDSC1; GDSC2; CTRP2 3.3664 9.1993 1.9124 23.1705
LC4-1 GDSC1; GDSC2 3.4293 8.5334 0.8051 13.6436
Ku812 GDSC1; GDSC2; CTRP2 3.4407 8.3629 2.3523 21.3495
KMS-27 CTRP2 3.4534 8.7323 2.2066 21.857
Hs 445 GDSC1; GDSC2 3.494 10.3911 -0.0703 17.8123
L-540 GDSC1; GDSC2; CTRP2 3.5018 7.1491 2.9054 19.0975
L-428 GDSC1; GDSC2; CTRP2 3.5255 8.2141 2.5036 20.5481
KYO-1 CTRP2 3.5533 8.3561 2.4721 20.5913
U266B1 GDSC1; GDSC2; CTRP2 3.6359 8.4898 2.5001 20.2614
DG-75 GDSC1; GDSC2 3.8322 9.2023 0.7955 12.6935
OCI-Ly3 CTRP2 3.8615 6.5663 3.5017 15.8283
HEL GDSC1; GDSC2; CTRP2 3.8943 8.2867 2.3874 14.554
H9 GDSC1; GDSC2 3.9314 6.6061 2.1559 5.1098
JeKo-1 GDSC1; GDSC2; CTRP2 3.9617 12.2172 1.0875 24.4476
CML-T1 GDSC1; GDSC2; CTRP2 3.9628 7.0014 3.4547 15.7144
SCC-3 GDSC2 4.0146 8.8691 1.1023 10.6532
Peer CTRP2 4.0934 7.1246 3.5468 14.997
KG-1 GDSC1; GDSC2 4.1283 8.6409 1.3009 9.3385
HDLM-2 GDSC1; GDSC2; CTRP2 4.1394 10.3363 2.1594 20.2422
ROS-50 GDSC1; GDSC2 4.2248 9.2873 0.0014 7.3437
SK-MM-2 GDSC1; GDSC2; CTRP2 4.2284 9.6156 2.5865 18.3917
LAMA-84 GDSC1; GDSC2; CTRP2 4.2482 11.2885 1.2363 18.503
MOLP-2 CTRP2 4.2866 16.3221 -0.624 28.5072
BE-13 GDSC1; GDSC2 4.3312 11.0642 0.2563 14.2275
ME1 GDSC1; GDSC2 4.5325 7.4205 2.1723 3.9017
Granta-519 GDSC1; GDSC2; CTRP2 4.5715 11.8522 1.8372 20.3808
MOLM-6 CTRP2 4.6443 9.0365 3.266 14.6804
TK [Human B-cell lymphoma] GDSC1; GDSC2 4.7006 9.5836 1.2523 8.4068
MOLT-13 GDSC1; GDSC2; CTRP2 4.7158 9.0825 3.3137 14.3156
MOTN-1 CTRP2 4.7409 10.2721 2.7657 16.4502
HD-MY-Z CTRP2 4.7743 8.472 3.6588 12.7791
Karpas-231 GDSC1; GDSC2 4.9996 6.2225 2.9226 0.2363
HEL 92.1.7 CTRP2 5.1643 7.2089 4.6294 7.8978
TF-1 CTRP2 5.4836 8.0235 4.5559 7.4301
OCI-M1 GDSC1; GDSC2; CTRP2 5.5394 6.4309 5.3548 4.0484
A3/Kawakami GDSC1; GDSC2; CTRP2 5.6392 6.247 5.5341 3.0825
REC-1 CTRP2 5.6411 8.7951 4.32 8.066
HuNS1 CTRP2 5.7279 10.0845 3.7549 10.2445
K-562 GDSC1; GDSC2; CTRP2 5.7444 10.9692 3.3277 11.9791
KO52 CTRP2 5.8301 8.9394 4.4146 7.2754
Toledo CTRP2 6.0086 8.032 5.0206 4.3729
SUP-B15 GDSC1; GDSC2; CTRP2 6.0656 12.6016 2.7834 13.5398
MEG-01 GDSC1; GDSC2 6.3527 8.6353 2.5742 0.4846
KMM-1 CTRP2 6.4272 9.9805 4.3855 6.2674
⏷ Show the Full List of 219 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 2.5757 6.9735 1.9699 25.2374
TE8 CTRP2 3.3518 10.7102 1.211 25.6335
TE-15 GDSC1; GDSC2 0.4886 4.3872 -0.606 21.3421
T.T GDSC1; GDSC2 0.6296 4.126 0.1306 26.1733
EC-GI-10 GDSC1; GDSC2; CTRP2 0.6517 4.889 0.4296 36.6005
OE21 GDSC1; GDSC2; CTRP2 0.8821 4.4934 0.7457 34.8285
TE-6 GDSC1; GDSC2; CTRP2 1.0483 6.097 0.5776 34.7381
TE-14 CTRP2 1.049 4.9773 0.8426 33.9435
KYSE-270 GDSC1; GDSC2 1.0819 6.0782 -0.1864 25.8646
KYSE-410 GDSC1; GDSC2; CTRP2 1.5223 6.8837 0.857 32.2741
TE-5 GDSC1; GDSC2; CTRP2 1.6221 5.3832 1.3813 30.2688
TE-4 GDSC1; GDSC2; CTRP2 1.641 5.4966 1.3765 30.2226
OE33 GDSC1; GDSC2; CTRP2 1.8376 7.0235 1.1531 30.3103
KYSE-520 GDSC1; GDSC2; CTRP2 2.0506 7.7733 1.1162 29.7467
TE-11 GDSC1; GDSC2; CTRP2 2.2709 5.8637 1.9742 26.1614
KYSE-70 GDSC1; GDSC2; CTRP2 2.2845 6.663 1.7569 26.8754
TE-8 GDSC1; GDSC2 2.2985 9.2384 -0.5272 23.2312
KYSE-150 GDSC1; GDSC2; CTRP2 2.3701 7.5703 1.5345 27.376
KYSE-30 CTRP2 2.6042 8.6003 1.3785 27.1965
TE-10 GDSC1; GDSC2; CTRP2 2.6118 6.594 2.1349 24.541
KYSE-140 GDSC1; GDSC2; CTRP2 2.629 6.2982 2.2448 24.0964
KYSE-510 GDSC1; GDSC2; CTRP2 2.7046 10.3795 0.7127 29.0092
OE19 GDSC1; GDSC2; CTRP2 2.8864 8.9306 1.5347 25.8443
KYSE-180 GDSC1; GDSC2; CTRP2 2.9803 7.4967 2.216 23.1539
TE-9 GDSC1; GDSC2; CTRP2 3.4389 6.7718 2.9736 19.0235
COLO 680N GDSC1; GDSC2; CTRP2 4.2228 10.6377 2.0963 20.2702
TE-1 GDSC1; GDSC2; CTRP2 4.7102 12.165 1.8117 20.1484
KYSE-450 GDSC1; GDSC2; CTRP2 6.3878 16.6718 1.0141 19.3394
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 5.1444 10.4295 3.0631 14.3389
PaTu 8988s CTRP2 0.6184 7.3187 -0.2684 38.4583
DAN-G GDSC1; GDSC2; CTRP2 1.225 7.6636 0.2682 34.96
Panc 02.03 GDSC1; GDSC2; CTRP2 1.4084 9.0555 -0.0669 35.1689
BxPC-3 GDSC1; GDSC2; CTRP2 1.5366 6.5296 0.9843 31.8348
HuP-T4 GDSC1; GDSC2; CTRP2 1.8005 8.9751 0.3796 32.7275
Panc 10.05 GDSC1; GDSC2; CTRP2 1.8496 9.3064 0.2949 32.7981
Panc 08.13 GDSC1; GDSC2; CTRP2 1.9628 8.1615 0.8746 30.7778
PL4 GDSC1; GDSC2 2.1024 6.8234 0.474 19.1788
Hs 766T GDSC1; GDSC2; CTRP2 2.1111 10.2687 0.1557 32.3443
TCC-Pan2 CTRP2 2.2899 7.8117 1.3579 28.2147
KP-1N GDSC1; GDSC2 2.3506 6.8923 0.6743 17.3733
L3.3 CTRP2 2.5535 7.4424 1.7787 25.9778
HPAF-II GDSC1; GDSC2; CTRP2 2.5702 10.0962 0.7021 29.4335
Panc 05.04 CTRP2 2.5891 19.2079 -3.5999 37.8431
AsPC-1 GDSC1; GDSC2; CTRP2 2.6237 8.612 1.3942 27.0861
Panc 03.27 GDSC1; GDSC2; CTRP2 2.6682 8.7984 1.3633 27.058
PK-59 CTRP2 2.8244 6.7456 2.3165 23.2477
HPAC GDSC1; GDSC2; CTRP2 2.8315 8.5381 1.6427 25.6307
SNU-213 CTRP2 2.8708 11.1129 0.5466 29.0227
Capan-2 GDSC1; GDSC2; CTRP2 3.0774 10.4377 1.0625 26.8682
MZ-PC-1 GDSC1; GDSC2 3.2121 6.1484 0.828 4.5447
KP-3 GDSC1; GDSC2; CTRP2 3.4597 8.6231 2.2605 21.6395
KP-2 GDSC1; GDSC2; CTRP2 3.6011 11.0846 1.2814 24.7361
MIA PaCa-2 GDSC1; GDSC2; CTRP2 3.6795 9.4519 2.1165 21.5835
SW1990 GDSC1; GDSC2; CTRP2 3.6862 8.085 2.7255 19.267
KP-4 GDSC1; GDSC2; CTRP2 4.1561 10.7567 1.9752 20.8832
PaTu 8902 GDSC1; GDSC2; CTRP2 4.2387 12.1052 1.4032 22.7088
YAPC GDSC1; GDSC2; CTRP2 4.3872 12.1361 1.5271 21.9215
HuP-T3 GDSC1; GDSC2; CTRP2 4.5717 13.4565 1.0493 23.0921
Panc 04.03 GDSC1; GDSC2; CTRP2 4.6309 11.5368 2.0466 19.4723
QGP-1 GDSC1; GDSC2; CTRP2 4.6455 10.795 2.4219 18.0171
SU.86.86 GDSC1; GDSC2; CTRP2 4.7586 10.7269 2.561 17.2133
CFPAC-1 GDSC1; GDSC2; CTRP2 4.9917 11.6214 2.3364 17.5484
PSN1 GDSC1; GDSC2; CTRP2 5.2559 13.0006 1.8892 18.6381
PaTu 8988t GDSC1; GDSC2; CTRP2 5.3334 14.3477 1.2863 20.591
Capan-1 GDSC1; GDSC2; CTRP2 5.3861 10.7274 3.134 13.5223
PK-45H CTRP2 6.4569 11.2631 3.7704 8.7789
SNU-410 CTRP2 7.4995 20.0867 0.196 19.8178
SUIT-2 GDSC1; GDSC2; CTRP2 7.7746 16.3672 2.2444 12.5696
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 77 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 5.3139 16.0038 0.4435 23.3137
CHL-1 GDSC1; GDSC2 -0.1528 5.1145 -1.0753 34.4617
A-388 GDSC1; GDSC2 -0.047 4.028 -0.9906 25.6138
VMRC-MELG GDSC2 0.2588 5.0254 -1.1294 25.0484
A-431 GDSC1; GDSC2 0.5456 3.7126 -0.2437 19.0516
MZ-MEL-2 GDSC1; GDSC2 0.6906 5.1944 -0.7866 21.5603
Hs 852.T CTRP2 0.7397 9.2992 -0.8721 39.1965
Hs 938.T GDSC1; GDSC2 0.7583 5.5667 -0.9005 21.9208
WM115 GDSC1; GDSC2; CTRP2 0.8219 6.5358 0.2035 36.5777
RPMI-7951 GDSC1; GDSC2; CTRP2 0.9363 5.6225 0.5791 35.1342
COLO 792 GDSC1; GDSC2; CTRP2 0.9702 5.7499 0.5843 34.9979
WM88 CTRP2 1.4386 6.0195 1.0247 32.0375
Mel Ho GDSC1; GDSC2; CTRP2 1.4544 7.0778 0.7192 32.9152
MMAc-SF GDSC1; GDSC2 1.4898 6.4518 -0.6642 18.071
CP50-MEL-B GDSC1; GDSC2 1.5378 6.3551 -0.5738 17.4046
WM35 GDSC1; GDSC2 1.7123 6.8232 0.0986 22.3059
A101D GDSC1; GDSC2; CTRP2 1.758 7.1154 1.0357 30.9419
WM266-4 CTRP2 1.8587 7.9079 0.86 31.1562
LOX-IMVI GDSC1; GDSC2; CTRP2 1.9942 7.4774 1.1641 29.7725
HMV-II GDSC1; GDSC2 2.093 7.4547 0.1594 20.7599
G-mel GDSC1; GDSC2 2.2629 4.7751 0.825 6.7078
IST-MEL1 GDSC1; GDSC2 2.3947 7.7902 0.2747 19.2555
WM1552C GDSC1; GDSC2 2.4043 6.2917 1.0168 15.4071
IGR-37 GDSC1; GDSC2; CTRP2 2.4243 8.4177 1.2635 28.1155
CP66-MEL GDSC1; GDSC2 2.4381 7.5691 -0.4284 13.8775
LB2518-MEL GDSC1; GDSC2 2.4396 6.5652 0.0726 10.91
DJM-1 GDSC1; GDSC2 2.5032 7.4302 -0.308 13.0039
G-361 GDSC1; GDSC2; CTRP2 2.7294 7.2642 2.033 24.5521
WM1799 CTRP2 2.8439 7.3838 2.1122 23.9292
451Lu GDSC1; GDSC2 2.8806 5.1102 1.1033 3.5693
COLO 783 GDSC1; GDSC2 2.8903 5.0803 1.1236 3.4315
UACC-62 GDSC1; GDSC2; CTRP2 2.9095 8.2477 1.8442 24.6981
WM793 GDSC1; GDSC2; CTRP2 3.0095 7.7564 2.1468 23.3215
Hs 294T CTRP2 3.0287 7.1286 2.4044 22.3236
HT-144 GDSC1; GDSC2; CTRP2 3.0428 8.5959 1.8394 24.3338
COLO 800 GDSC1; GDSC2; CTRP2 3.0515 10.4222 1.0436 27.0011
M14 GDSC1; GDSC2 3.1044 10.2009 -0.3005 19.8998
MZ-MEL-7 GDSC1; GDSC2 3.2772 7.934 0.0182 9.1797
Hs 944.T CTRP2 3.4807 12.475 0.5042 27.4851
RVH-421 GDSC1; GDSC2; CTRP2 3.5013 10.0678 1.6563 23.7172
GAK GDSC1; GDSC2 3.5119 7.6246 1.3268 10.6385
WM278 GDSC1; GDSC2 3.5308 10.8657 -0.2773 18.6598
Hs 940.T GDSC1; GDSC2; CTRP2 3.6312 8.8946 2.3177 20.9619
SK-MEL-24 GDSC1; GDSC2; CTRP2 3.6949 9.4385 2.138 21.4634
SH-4 GDSC1; GDSC2 3.7304 9.9211 0.3563 15.1687
K029AX CTRP2 3.7989 8.7207 2.566 19.5749
LB373-MEL-D GDSC1; GDSC2 3.8825 9.5443 -0.3421 9.9068
COLO 679 GDSC1; GDSC2 4.0042 7.4977 1.7718 7.0559
SK-MEL-3 GDSC1; GDSC2; CTRP2 4.0288 10.6172 1.9189 21.4079
COLO 829 GDSC1; GDSC2; CTRP2 4.0441 9.5485 2.4362 19.435
MDA-MB-435S CTRP2 4.0767 9.2249 2.6181 18.6523
IGR-39 CTRP2 4.147 9.5112 2.5553 18.7168
A2058 GDSC1; GDSC2; CTRP2 4.1924 7.1211 3.6533 14.314
MeWo GDSC1; GDSC2; CTRP2 4.2655 14.0979 0.4535 25.6643
WM983B CTRP2 4.2704 10.3028 2.3022 19.3788
IPC-298 GDSC1; GDSC2; CTRP2 4.7671 11.0354 2.4182 17.7475
A-375 GDSC1; GDSC2; CTRP2 4.8316 11.3465 2.3253 17.9552
Hs 895.T CTRP2 4.9307 13.6948 1.2556 21.5841
UACC-257 GDSC1; GDSC2; CTRP2 4.9629 12.2031 2.023 18.7955
Mel JuSo GDSC1; GDSC2; CTRP2 5.1206 12.5613 1.9873 18.5748
Hs 934.T CTRP2 5.124 17.9397 -0.6867 26.7973
HMCB CTRP2 5.1281 9.9003 3.3081 13.3795
SK-MEL-5 GDSC1; GDSC2; CTRP2 5.2237 10.4775 3.1116 13.9669
IGR-1 GDSC1; GDSC2; CTRP2 5.225 8.7589 3.9556 10.4992
CJM [Human melanoma] CTRP2 5.4407 8.7645 4.1534 9.1952
Malme-3M CTRP2 5.7768 12.6597 2.5112 15.1883
Hs 936.T CTRP2 6.1116 12.4929 2.8759 13.0817
SK-MEL-1 GDSC1; GDSC2; CTRP2 6.1117 8.1412 5.0515 4.0453
SK-MEL-30 GDSC1; GDSC2; CTRP2 6.1505 12.184 3.0626 12.256
SK-MEL-31 GDSC1; GDSC2; CTRP2 6.7117 15.9108 1.6557 16.5472
SK-MEL-28 GDSC1; GDSC2; CTRP2 7.2118 20.23 -0.1005 21.1698
SK-MEL-2 GDSC1; GDSC2; CTRP2 7.5405 8.5295 5.7244 0.1061
COLO 741 CTRP2 7.6466 11.0756 4.7056 3.1829
Hs 839.T CTRP2 8.7128 22.7114 -0.1833 18.8883
Hs 688(A).T CTRP2 8.9207 27.2622 -2.2732 23.6178
WT2-iPS GDSC1; GDSC2; CTRP2 9.186 18.0101 2.4337 9.7869
EquiPSC Line K2 GDSC1; GDSC2 2.8338 7.8129 -0.2442 11.7683
⏷ Show the Full List of 77 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-GT-4 GDSC1; GDSC2 -0.0076 5.0483 -0.895 33.175
OACP4 C GDSC1; GDSC2 0.112 5.5165 -0.9538 32.8663
TE-12 GDSC1; GDSC2 0.2674 5.7177 -1.4454 26.5505
FLO-1 GDSC1; GDSC2 0.7132 9.758 -2.2642 34.4565
HCE-4 GDSC1; GDSC2 0.88 8.7716 -2.3592 28.0914
KYAE-1 GDSC1; GDSC2 1.059 5.9584 -0.1567 25.8172
OACM5.1 C GDSC1; GDSC2 2.0652 7.4934 0.1145 21.0648
ESO-51 GDSC1; GDSC2 2.3101 6.2997 0.9239 16.194
KYSE-220 GDSC1; GDSC2 2.3752 5.4073 1.4138 13.3671
ESO-26 GDSC1; GDSC2 2.7046 8.0356 0.4327 17.5452
KYSE-50 GDSC1; GDSC2 3.288 6.5787 1.6652 9.3412
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2; CTRP2 -0.2635 5.5998 -0.7235 42.9533
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NB69 GDSC1; GDSC2 -1.668 3.7806 -2.2556 45.2978
CHP-212 GDSC1; GDSC2; CTRP2 0.0941 5.7236 -0.3646 40.7478
NB1 GDSC1; GDSC2; CTRP2 0.1658 4.4522 -0.017 39.6675
SJNB-5 GDSC1; GDSC2 0.5847 6.8674 -1.6946 26.4526
SJNB-12 GDSC1; GDSC2 0.8579 7.1646 -0.9042 29.6671
KP-N-RT-BM-1 GDSC2 1.0286 3.474 0.3527 13.6433
KP-N-SI9s CTRP2 1.1742 5.7129 0.8162 33.589
SK-N-FI GDSC1; GDSC2; CTRP2 1.3429 6.9115 0.653 33.4897
IMR-32 CTRP2 1.4238 3.9394 1.384 30.916
SK-N-DZ GDSC1; GDSC2; CTRP2 1.5929 4.9025 1.4437 30.1565
NB(TU)1 GDSC1; GDSC2 1.7781 6.7435 0.2004 21.5961
NH-12 GDSC1; GDSC2 1.7833 7.0087 0.0793 22.1578
SiMa GDSC1; GDSC2; CTRP2 1.9081 5.9846 1.5465 28.7848
SJNB-14 GDSC1; GDSC2 2.0847 8.6749 -0.4446 23.5458
SK-N-MC-IXC GDSC1; GDSC2 2.2341 5.5129 0.4347 9.2349
KP-N-YS GDSC1; GDSC2 2.2766 6.5649 -0.0562 12.1338
SK-N-BE(2)-M17 GDSC1; GDSC2 2.3579 7.7264 0.2724 19.3793
Kelly GDSC1; GDSC2; CTRP2 2.3954 8.6497 1.1387 28.6075
SK-N-SH GDSC1; GDSC2; CTRP2 2.4732 10.0995 0.6014 30.0164
SJNB-10 GDSC1; GDSC2 2.6447 8.5128 0.1425 19.1496
NH-6 CTRP2 2.6455 6.5139 2.197 24.2171
SJNB-6 GDSC1; GDSC2 2.6898 7.2007 -0.0502 10.994
SJNB-13 GDSC1; GDSC2 2.7159 5.6582 1.617 11.2052
MHH-NB-11 GDSC1; GDSC2; CTRP2 2.7563 10.4978 0.7117 28.863
TGW GDSC1; GDSC2 2.761 8.488 0.2577 18.251
GI-ME-N GDSC1; GDSC2 2.8964 11.5991 -1.1764 24.0683
LA-N-6 GDSC1; GDSC2 3.1483 8.7842 -0.4892 12.3839
SK-N-BE(2) CTRP2 3.1646 12.856 0.0177 29.679
SJNB-17 GDSC1; GDSC2 3.3181 5.4337 1.2173 2.19
CHP-134 GDSC1; GDSC2 3.3387 8.8714 0.5612 15.1403
SK-N-AS GDSC1; GDSC2; CTRP2 3.7898 9.6746 2.125 21.2625
CHP-126 GDSC1; GDSC2; CTRP2 4.0505 9.2531 2.5791 18.87
GOTO GDSC1; GDSC2 4.0615 6.8023 2.1529 4.8623
IMR-5 GDSC1; GDSC2 4.0832 8.1848 1.492 8.4072
SJNB-7 GDSC1; GDSC2 4.8616 14.2831 -0.9344 18.2596
KP-N-YN GDSC1; GDSC2; CTRP2 6.0946 7.6879 5.2642 3.1839
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-478 CTRP2 0.6453 7.7362 -0.3833 38.6008
SNU-1079 CTRP2 0.6716 4.6712 0.4906 36.3514
SNU-308 CTRP2 1.2889 5.1848 1.0615 32.4271
HuCC-T1 GDSC1; GDSC2; CTRP2 2.0961 8.6838 0.8094 30.5538
SNU-1196 CTRP2 3.4402 8.1365 2.4471 20.9954
HuH-28 CTRP2 4.095 11.4191 1.5991 22.3855
SNU-869 CTRP2 9.6794 24.8935 -0.5493 18.4162
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 91 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-BR-3 CTRP2 -1.2621 5.3155 -1.7428 48.8766
MDA-MB-361 GDSC1; GDSC2; CTRP2 -1.0941 3.7731 -1.264 50.7614
Evsa-T GDSC1; GDSC2 -1.0477 1.797 -1.1334 38.926
HCC2157 GDSC1; GDSC2 -0.7326 2.7815 -0.9679 36.7389
MDA-MB-415 GDSC1; GDSC2; CTRP2 -0.4685 3.4448 -0.5582 43.5923
MDA-MB-175-VII GDSC1; GDSC2 -0.2784 3.2261 -0.5815 33.0909
AU565 GDSC1; GDSC2; CTRP2 -0.0165 6.4519 -0.6856 41.8173
MDA-MB-453 GDSC1; GDSC2; CTRP2 0.0017 4.5572 -0.2118 40.8054
EFM-19 GDSC1; GDSC2 0.0597 8.1377 -2.149 36.5736
YMB-1-E GDSC2 0.0973 3.3075 -0.5372 22.5614
EFM-192A GDSC1; GDSC2; CTRP2 0.2223 3.3127 0.1782 38.9219
UACC-893 GDSC1; GDSC2 0.3396 3.3707 -0.309 20.1922
OCUB-M GDSC1; GDSC2 0.3528 2.6497 0.2373 26.7459
CAL-148 GDSC2; CTRP2 0.3854 3.4073 0.3412 37.8392
MDA-MB-330 GDSC1; GDSC2 0.4774 4.6436 -0.7356 22.0294
HCC70 GDSC1; GDSC2 0.6352 5.2644 -0.2999 28.0081
MCF-7 GDSC1; GDSC2; CTRP2 0.6466 6.5536 0.007 37.7232
ZR-75-1 CTRP2 0.6554 6.549 0.0181 37.6631
CAL-51 GDSC1; GDSC2; CTRP2 1.0002 3.9765 0.9364 33.8144
HCC1569 GDSC1; GDSC2 1.0383 5.0344 -0.3779 17.9174
HCC1954 GDSC1; GDSC2; CTRP2 1.1019 3.7212 1.0648 33.0506
UACC-812 GDSC2 1.1626 6.8487 -0.4549 26.6605
HDQ-P1 GDSC1; GDSC2; CTRP2 1.1755 8.8708 -0.24 36.3703
Hs 578T GDSC1; GDSC2; CTRP2 1.2511 7.3893 0.3928 34.5371
HCC1143 GDSC1; GDSC2; CTRP2 1.5581 6.9107 0.8871 32.0624
T-47D GDSC1; GDSC2; CTRP2 1.577 11.4823 -0.9262 36.478
MFM-223 GDSC1; GDSC2 1.668 5.408 0.7088 19.382
CAMA-1 GDSC1; GDSC2; CTRP2 1.7569 4.9193 1.6175 29.0341
BT-20 GDSC1; GDSC2; CTRP2 1.8194 5.7666 1.5063 29.2062
HMC-1-8 CTRP2 2.0485 6.2658 1.6211 28.0829
HCC1599 GDSC2 2.1594 5.9728 0.1448 11.2018
BT-474 GDSC1; GDSC2; CTRP2 2.3267 9.6563 0.6438 30.3331
HCC2218 GDSC1; GDSC2; CTRP2 2.4286 9.2724 0.9136 29.215
MDA-MB-468 GDSC1; GDSC2; CTRP2 2.4425 6.0766 2.1047 25.1681
CAL-85-1 GDSC1; GDSC2; CTRP2 2.4551 7.6666 1.5896 26.9292
MDA-MB-436 GDSC1; GDSC2 2.4766 7.8768 0.3066 18.7959
ZR-75-30 GDSC1; GDSC2; CTRP2 2.5145 10.8982 0.2866 30.7815
MRK-nu-1 GDSC1; GDSC2 2.6333 4.8693 1.9195 9.776
JIMT-1 GDSC1; GDSC2; CTRP2 2.7163 8.6069 1.4934 26.4791
HCC1395 GDSC1; GDSC2; CTRP2 2.77 9.3374 1.2394 27.1697
HCC202 GDSC1; GDSC2; CTRP2 2.7856 10.3155 0.8235 28.4412
CAL-120 GDSC1; GDSC2; CTRP2 3.0451 9.5252 1.4399 25.7156
COLO 824 GDSC1; GDSC2 3.2838 10.6311 -0.3645 19.6466
HCC1806 GDSC1; GDSC2; CTRP2 3.4599 8.029 2.5125 20.6952
HCC1937 GDSC1; GDSC2; CTRP2 3.7499 11.2811 1.3331 24.1751
HCC1419 GDSC1; GDSC2; CTRP2 3.8591 10.5905 1.7663 22.3901
HCC1187 GDSC1; GDSC2 3.9341 12.691 -0.8628 20.0803
DU4475 GDSC1; GDSC2; CTRP2 4.1939 7.2505 3.6033 14.502
BT-549 GDSC1; GDSC2; CTRP2 4.8289 12.151 1.9271 19.4538
HCC38 GDSC1; GDSC2; CTRP2 5.078 11.4491 2.4998 16.7242
HCC1500 GDSC1; GDSC2; CTRP2 5.4999 10.7577 3.2199 12.9292
BT-483 GDSC1; GDSC2 5.5756 14.1093 -0.3285 14.2236
KPL-1 CTRP2 5.6355 15.0018 1.2205 20.1704
Hs 578Bst CTRP2 6.0278 18.7009 -0.2976 23.9356
HCC1428 GDSC1; GDSC2; CTRP2 7.0801 9.7638 4.9607 2.9009
MDA-MB-231 GDSC1; GDSC2; CTRP2 7.461 16.6118 1.8898 14.3805
MDA-MB-157 GDSC1; GDSC2; CTRP2 8.167 20.676 0.4134 18.0486
BT 239 CTRP2 -0.722 7.5661 -1.8052 46.2678
BT 231 CTRP2 0.6704 7.3146 -0.2106 38.1348
BT 248 CTRP2 0.7092 8.1532 -0.4647 38.5293
BT 139 CTRP2 0.7818 7.5989 -0.1876 37.6659
BT 271 CTRP2 1.2489 6.3507 0.7242 33.6058
BT 416 CTRP2 1.2517 5.3076 0.9951 32.7655
BT 228 CTRP2 1.5418 10.1571 -0.3844 35.4607
BT147 CTRP2 1.6272 8.5307 0.3737 33.3105
BT 245 CTRP2 2.0233 8.5978 0.7671 30.9095
BT 131 CTRP2 2.1394 9.5515 0.4944 31.3363
BT 286 CTRP2 2.1405 8.4607 0.9461 29.9981
BT 482 CTRP2 2.278 10.4651 0.2403 31.6109
BT 428 CTRP2 2.2903 6.1712 1.9121 26.3175
BT 172 CTRP2 2.4973 7.7081 1.6191 26.7007
BT 330 CTRP2 2.5455 7.1613 1.8716 25.676
BT 440 CTRP2 2.6804 11.3852 0.2312 30.4509
BT 159 CTRP2 3.0021 13.0349 -0.2246 30.7417
BT 444 CTRP2 3.0328 11.993 0.2976 29.2784
BT 359 CTRP2 3.136 13.7891 -0.4561 30.9512
BT 504 CTRP2 3.2696 10.6774 1.1445 26.0739
BT 422 CTRP2 3.4819 10.1954 1.5783 24.0414
BT164 CTRP2 3.5246 7.166 2.9235 18.9641
BT 145 CTRP2 3.545 7.7328 2.7234 19.663
BT 328 CTRP2 3.8076 10.6437 1.6909 22.7905
BT 232 CTRP2 3.92 10.5093 1.864 21.8831
BT 187 CTRP2 3.9939 14.7644 -0.1236 27.9328
BT 112 CTRP2 4.0623 7.953 3.1724 16.5306
BT 333 CTRP2 4.6458 11.7519 1.9552 19.7752
BT 216 CTRP2 5.1834 12.9543 1.8481 18.9465
BT 320 CTRP2 5.4254 13.6035 1.7374 18.8216
BT 340 CTRP2 5.5794 16.2679 0.5401 22.4598
BT 224 CTRP2 5.6374 9.3173 4.0575 9.1701
BT 179 CTRP2 5.9651 12.401 2.7998 13.673
BT 498 CTRP2 6.8833 21.6383 -1.0649 24.2669
⏷ Show the Full List of 91 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 0.8339 4.4191 0.7052 35.1233
Cancer Drug Sensitivity Data Curated from 69 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-MG-1 GDSC1; GDSC2 -0.3184 6.5987 -1.8551 37.5267
D-336MG GDSC1; GDSC2 -0.2851 7.052 -2.6144 33.4149
KG-1-C CTRP2 -0.279 11.5185 -2.8559 45.2597
H4 GDSC1; GDSC2 -0.1815 4.2815 -0.8007 33.6049
42-MG-BA GDSC1; GDSC2; CTRP2 0.0272 6.2954 -0.5926 41.4685
YH-13 GDSC1; GDSC2; CTRP2 0.1039 6.4713 -0.56 41.088
D-423MG GDSC1; GDSC2 0.1158 3.924 -0.7775 23.7982
GaMG GDSC1; GDSC2; CTRP2 0.5743 6.6478 -0.1004 38.252
SNB-75 GDSC1; GDSC2; CTRP2 0.6705 7.2112 -0.1758 38.0566
MOG-G-UVW GDSC1; GDSC2 0.7441 3.3375 0.5044 23.9485
D-566MG GDSC1; GDSC2 0.7631 3.7746 -0.0509 17.0709
MOG-G-CCM GDSC1; GDSC2 0.8752 7.4332 -1.0106 29.9961
D283 Med GDSC1; GDSC2; CTRP2 0.9092 6.413 0.3353 35.9116
PFSK-1 GDSC1; GDSC2 0.9406 6.7465 -0.6303 28.285
SF539 GDSC1; GDSC2; CTRP2 1.2458 6.6917 0.6175 33.9279
GI-1 GDSC1; GDSC2 1.2803 5.4088 0.3114 22.8065
D-542MG GDSC1; GDSC2 1.392 6.2657 -0.6585 18.3624
D-502MG GDSC1; GDSC2 1.4154 7.534 -1.2681 21.5101
T98G GDSC1; GDSC2; CTRP2 1.5019 6.8964 0.8307 32.4221
D-247MG GDSC1; GDSC2 1.5598 7.3152 -1.0327 19.8373
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 1.6388 7.995 -0.5319 25.3808
Becker GDSC1; GDSC2; CTRP2 1.736 7.3324 0.9371 31.3201
D-245MG GDSC2 1.8371 4.9665 0.3789 10.7328
SW1088 GDSC1; GDSC2; CTRP2 2.0676 9.3457 0.5065 31.5259
Hs 683 GDSC1; GDSC2; CTRP2 2.2638 7.1302 1.5781 27.5546
Onda 11 GDSC1; GDSC2 2.3686 5.5675 0.5134 8.382
LN-405 GDSC1; GDSC2 2.4259 9.4271 -0.5062 22.7531
Onda 10 GDSC1; GDSC2 2.4339 4.3114 1.1829 4.0403
D-263MG GDSC1; GDSC2 2.4464 8.6591 -0.1074 20.9193
KNS-81-FD GDSC1; GDSC2 2.4665 7.8259 -0.5339 14.3998
LNZTA3WT4 GDSC1; GDSC2 2.5448 6.0292 0.4195 8.5096
M059J GDSC1; GDSC2 2.5688 7.1254 0.7612 16.2586
YKG-1 GDSC1; GDSC2; CTRP2 2.6648 8.5313 1.4706 26.708
Daoy GDSC1; GDSC2; CTRP2 2.6838 8.8857 1.3429 27.0799
KALS-1 GDSC1; GDSC2; CTRP2 2.7112 10.8349 0.5136 29.5735
SW1783 GDSC1; GDSC2; CTRP2 2.8871 8.087 1.8857 24.6155
AM-38 GDSC1; GDSC2 2.9821 5.6129 1.8822 8.9641
CAS-1 GDSC1; GDSC2; CTRP2 3.016 9.7741 1.2997 26.2678
M059K CTRP2 3.0367 8.6394 1.8147 24.4384
GB-1 GDSC1; GDSC2; CTRP2 3.0636 8.5643 1.8744 24.1499
SF268 GDSC1; GDSC2; CTRP2 3.1872 8.7405 1.9281 23.6093
KINGS-1 GDSC1; GDSC2 3.3437 11.6814 -0.8397 21.5415
SNU-1105 CTRP2 3.3503 12.741 0.2516 28.5493
GMS-10 CTRP2 3.5896 12.3047 0.6903 26.6467
U-118MG GDSC1; GDSC2; CTRP2 3.6718 10.5747 1.5902 23.4972
LN-18 GDSC1; GDSC2; CTRP2 3.7577 7.4274 3.0709 17.75
SF295 GDSC1; GDSC2; CTRP2 4.0539 9.676 2.3864 19.6
SF126 GDSC1; GDSC2; CTRP2 4.2402 11.5417 1.6779 21.7488
DBTRG-05MG GDSC1; GDSC2; CTRP2 4.3117 10.4695 2.2623 19.4286
SNU-466 CTRP2 4.6769 12.34 1.6951 20.6441
SNU-738 CTRP2 4.7003 7.8994 3.8489 12.1987
U-251MG GDSC1; GDSC2; CTRP2 4.7008 9.6255 3.0398 15.4533
ONS-76 GDSC1; GDSC2; CTRP2 4.7054 8.1417 3.7436 12.6078
GOS-3 CTRP2 4.7524 11.4209 2.2158 18.5547
A-172 GDSC1; GDSC2; CTRP2 4.8698 10.1899 2.9266 15.5103
SNU-201 CTRP2 4.9298 10.0919 3.0304 14.9558
NMC-G1 GDSC1; GDSC2; CTRP2 4.9621 11.965 2.1399 18.3608
DK-MG GDSC1; GDSC2; CTRP2 5.003 12.346 1.9885 18.8329
TM-31 CTRP2 5.4126 12.6228 2.2149 17.0876
SNU-489 CTRP2 5.4365 12.9281 2.0837 17.5298
SNU-626 CTRP2 5.5309 10.9078 3.1725 13.0572
U-87MG ATCC GDSC1; GDSC2; CTRP2 5.6364 18.4293 -0.4913 25.2328
KNS-81 CTRP2 5.7296 11.6288 2.9858 13.4023
8-MG-BA GDSC1; GDSC2; CTRP2 5.745 13.0861 2.271 16.1775
LN-229 GDSC1; GDSC2; CTRP2 5.9207 11.6629 3.1314 12.427
D-392MG GDSC1; GDSC2 5.9517 15.5364 -0.7568 15.3104
KNS-60 CTRP2 6.08 14.5586 1.8169 17.1852
CCF-STTG1 CTRP2 6.3961 11.0021 3.8522 8.5485
KNS-42 GDSC1; GDSC2; CTRP2 7.7674 14.4671 3.1683 9.0575
⏷ Show the Full List of 69 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1; GDSC2 -0.9119 2.6971 -1.1442 38.3792
ETK-1 GDSC1; GDSC2 0.8508 5.0857 0 25.8998
TGBC1TKB GDSC1; GDSC2 1.3129 4.4521 0.743 20.5554
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA GDSC1; GDSC2; CTRP2 -0.9402 4.5539 -1.229 46.8626
JHUEM-2 CTRP2 0.0887 4.337 -0.1884 36.2694
JHUEM-7 CTRP2 0.6013 4.2042 0.4868 36.619
JHUEM-1 CTRP2 0.7471 3.6325 0.7014 35.4395
MFE-280 GDSC1; GDSC2 0.9219 6.0856 -0.353 27.199
HEC-1-A CTRP2 1.0977 7.8073 0.0793 35.8893
HEC-59 CTRP2 1.7361 6.3093 1.2677 30.2696
MFE-319 GDSC1; GDSC2; CTRP2 2.1156 5.3515 1.9241 26.8276
HEC-1-B CTRP2 2.1647 8.4487 0.9764 29.8286
JHUEM-3 CTRP2 2.2397 5.7525 1.9681 26.2809
HEC-151 CTRP2 2.5419 5.962 2.2442 24.3668
ESS-1 GDSC1; GDSC2; CTRP2 2.6528 7.7228 1.7797 25.6775
EN GDSC1; GDSC2; CTRP2 2.9609 7.7116 2.1125 23.5864
HEC-6 CTRP2 3.0566 7.1114 2.4407 22.1091
MFE-296 GDSC1; GDSC2; CTRP2 3.1181 8.2745 2.0524 23.3544
RL95-2 GDSC1; GDSC2; CTRP2 3.2324 6.799 2.7408 20.4892
HEC-251 CTRP2 4.2975 9.1724 2.8617 17.1442
HEC-50B CTRP2 4.5198 10.5151 2.439 18.2499
HEC-108 CTRP2 4.9695 7.1336 4.4635 9.0609
EFE-184 CTRP2 5.1602 13.133 1.7387 19.3926
KLE GDSC1; GDSC2; CTRP2 5.636 16.4052 0.5198 22.4029
HEC-265 CTRP2 5.8777 8.0171 4.9159 5.0751
Ishikawa (Heraklio) 02 ER- CTRP2 5.8874 8.5032 4.6818 6.0378
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-140 GDSC1; GDSC2 -0.7553 2.2954 -1.0925 29.3672
LB2241-RCC GDSC1; GDSC2 -0.2334 3.2518 -0.8651 25.7746
LB1047-RCC GDSC1; GDSC2 -0.2333 3.7375 -1.0614 26.7884
CAL-54 GDSC1; GDSC2; CTRP2 -0.1485 4.844 -0.4283 41.9093
HA7-RCC GDSC1; GDSC2 -0.1314 3.7454 -0.958 25.81
KTCTL-195 GDSC1; GDSC2 -0.1105 4.0467 -0.6443 32.6796
KTCTL-26A GDSC1; GDSC2 -0.0633 3.1805 -0.6564 23.9079
BFTC-909 GDSC1; GDSC2; CTRP2 0.1863 6.5606 -0.4968 40.6292
NCC021 GDSC1; GDSC2 0.2566 4.652 -0.9595 24.1837
LB996-RCC GDSC1; GDSC2 0.2647 4.7025 -0.472 30.3443
KTCTL-1M GDSC1; GDSC2 0.3257 4.2432 -0.7043 22.5357
KTCTL-13 GDSC1; GDSC2 0.4047 4.9364 -0.9437 23.5069
UO-31 GDSC1; GDSC2; CTRP2 0.5041 5.2636 0.192 37.8061
A-704 GDSC1; GDSC2 0.9896 7.1102 -0.7477 28.5688
KTCTL-21 GDSC1; GDSC2 1.1573 5.989 -0.734 19.5809
SW13 GDSC1; GDSC2 1.2855 6.6724 -0.2511 25.4055
BB65-RCC GDSC1; GDSC2 1.3374 7.2052 -1.1735 21.2959
RXF 393L GDSC1; GDSC2 1.3628 4.9773 -0.0482 14.8909
TK-10 GDSC1; GDSC2 1.6244 6.9912 -0.0664 23.378
A-498 GDSC1; GDSC2; CTRP2 1.6465 8.213 0.5173 32.8506
NCC010 GDSC1; GDSC2 1.6918 7.0781 -0.8003 18.1724
769-P GDSC1; GDSC2; CTRP2 2.2779 7.1826 1.5751 27.5212
786-O GDSC1; GDSC2; CTRP2 2.2932 6.1681 1.9162 26.294
SW156 GDSC1; GDSC2 2.318 4.8681 0.8216 6.5846
KMRC-1 GDSC1; GDSC2; CTRP2 2.6471 7.6506 1.8012 25.6191
KMRC-2 CTRP2 3.5672 9.7702 1.8586 22.8224
OS-RC-2 GDSC1; GDSC2; CTRP2 4.094 12.3752 1.136 23.9594
VMRC-RCW GDSC1; GDSC2; CTRP2 4.1614 7.0688 3.6409 14.4475
TUHR10TKB CTRP2 4.3316 6.3387 4.0872 12.2792
Caki-2 CTRP2 4.4295 9.6444 2.7692 17.1815
SN12C GDSC1; GDSC2 4.5152 11.8669 -0.0014 15.0275
SNU-1272 CTRP2 4.8267 13.06 1.4765 21.0665
VMRC-RCZ GDSC1; GDSC2; CTRP2 4.8948 13.8265 1.1582 21.99
KMRC-20 GDSC1; GDSC2; CTRP2 5.132 12.0574 2.2473 17.5751
TUHR4TKB CTRP2 5.6528 11.9378 2.7653 14.4435
TUHR14TKB CTRP2 5.9727 23.8299 -2.9081 39.7759
Caki-1 GDSC1; GDSC2; CTRP2 6.2482 15.7092 1.3808 18.3873
ACHN GDSC1; GDSC2; CTRP2 6.4418 17.2102 0.7891 19.9563
RCC10RGB GDSC1; GDSC2; CTRP2 7.6576 19.9682 0.377 19.0116
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 58 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 320 CTRP2 -0.3885 7.5516 -1.4387 44.4643
NCI-H508 GDSC1; GDSC2; CTRP2 -0.3449 6.2428 -0.9837 43.7115
DiFi GDSC1; GDSC2 -0.3027 3.0268 -0.5572 33.203
SNU-81 GDSC1; GDSC2; CTRP2 -0.2298 3.8532 -0.3527 42.1037
LoVo GDSC1; GDSC2; CTRP2 0.3316 6.6329 -0.3602 39.7701
NCI-H747 GDSC1; GDSC2; CTRP2 0.4816 5.4293 0.1297 38.0539
CaR-1 GDSC1; GDSC2 0.5552 4.6646 -0.1469 27.7398
COLO 320HSR GDSC1; GDSC2 0.5966 3.9386 0.159 26.1751
SW48 GDSC1; GDSC2; CTRP2 0.8316 7.288 -0.0268 37.1104
C2BBe1 GDSC1; GDSC2; CTRP2 1.0175 5.6668 0.6567 34.6176
HCT 15 GDSC1; GDSC2; CTRP2 1.1042 6.5212 0.5156 34.7153
T84 GDSC1; GDSC2; CTRP2 1.2068 6.4346 0.6535 33.96
SNU-C1 GDSC1; GDSC2; CTRP2 1.2463 5.8478 0.8604 33.2043
GP5d GDSC1; GDSC2 1.2981 5.8432 0.1383 23.5723
SK-CO-1 GDSC1; GDSC2; CTRP2 1.3777 7.1618 0.6078 33.5003
GP2d CTRP2 1.4028 8.3155 0.2178 34.4773
HT115 GDSC1; GDSC2; CTRP2 1.4281 5.1288 1.2237 31.4326
SW948 GDSC1; GDSC2; CTRP2 1.4666 4.6769 1.3445 30.9053
SNU-175 GDSC2 1.5034 9.0076 -1.1493 28.2549
MDST8 GDSC1; GDSC2; CTRP2 1.5051 4.5815 1.3998 30.5936
SNU-407 GDSC1; GDSC2; CTRP2 1.7381 7.051 1.0358 31.0064
SNU-C4 CTRP2 1.7756 5.7348 1.4665 29.4823
LS123 GDSC1; GDSC2; CTRP2 1.9585 9.1267 0.4836 31.9339
HT-55 GDSC1; GDSC2; CTRP2 1.9651 7.511 1.1207 30.0041
HT-29 GDSC1; GDSC2; CTRP2 2.2284 9.8562 0.4559 31.1705
HCC2998 GDSC1; GDSC2 2.2487 7.9674 0.0537 20.7734
SNU-283 GDSC2 2.3785 6.0283 0.2919 9.7301
SNU-C5 GDSC1; GDSC2; CTRP2 2.3861 7.6756 1.5123 27.4024
LS513 GDSC1; GDSC2; CTRP2 2.4111 5.2035 2.2732 24.6761
CCK-81 GDSC1; GDSC2; CTRP2 2.483 7.4256 1.7091 26.4332
LS180 GDSC1; GDSC2; CTRP2 2.5307 6.681 2.0188 25.2004
SW1463 GDSC1; GDSC2 2.5338 8.0251 0.2851 18.7841
HCT 8 CTRP2 2.5486 5.9477 2.2553 24.3066
OUMS-23 CTRP2 2.6544 4.9654 2.5738 22.8582
SW626 GDSC1; GDSC2 2.7731 8.0983 0.4622 17.1984
KM12 GDSC1; GDSC2; CTRP2 2.7738 5.7248 2.557 22.5392
SNU-C2A CTRP2 2.8344 8.8267 1.5248 26.0283
LS411N GDSC1; GDSC2; CTRP2 3.0162 7.7545 2.1546 23.2735
CL-11 GDSC1; GDSC2; CTRP2 3.1502 10.7573 0.9888 26.9006
NCI-H716 GDSC1; GDSC2; CTRP2 3.2039 8.5931 2.0083 23.2729
SNU-1040 GDSC1 3.2976 11.1186 -1.5282 20.3147
SNU-C2B GDSC1; GDSC2 3.3308 9.3717 0.3044 16.4478
SW1417 GDSC1; GDSC2; CTRP2 3.8863 9.6158 2.2483 20.5515
SNU-503 CTRP2 3.9784 12.0349 1.1914 24.0656
LS1034 GDSC1; GDSC2; CTRP2 4.0654 8.3174 3.0168 17.1294
CW-2 GDSC1; GDSC2; CTRP2 4.3013 9.6785 2.6283 18.0482
COLO205 GDSC1; GDSC2; CTRP2 4.4053 11.2493 1.9755 20.2721
SW1116 GDSC1; GDSC2 4.4602 9.4604 1.1418 9.4716
SNU-61 GDSC1; GDSC2; CTRP2 4.49 9.9581 2.6782 17.3915
COLO201 CTRP2 4.6223 9.1348 3.198 15.0071
HCC-56 CTRP2 4.7098 7.7589 3.9218 11.8832
SW837 GDSC1; GDSC2 4.8047 10.527 0.8678 10.1771
SW620 GDSC1; GDSC2; CTRP2 4.8671 10.4082 2.8176 15.9515
RKO GDSC1; GDSC2; CTRP2 5.3035 13.8002 1.5329 19.8081
COLO 678 GDSC1; GDSC2; CTRP2 5.6047 9.9438 3.7171 10.6572
RCM-1 [Human ESC] GDSC1; GDSC2; CTRP2 5.9043 14.4956 1.7015 17.9525
HCT 116 GDSC1; GDSC2; CTRP2 6.088 7.3351 5.435 2.4786
DLD-1 CTRP2 6.2381 8.5778 4.9352 4.3015
⏷ Show the Full List of 58 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 1.8239 8.562 -0.6316 25.1772
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-182 CTRP2 0.4559 7.6283 -0.5502 39.6597
HuH-6 CTRP2 0.9234 4.1456 0.8367 34.3982
Hep 3B2.1-7 GDSC1; GDSC2; CTRP2 1.3735 5.5644 1.0695 32.1149
Li-7 CTRP2 1.4074 6.0193 0.9907 32.2496
Hep-G2 CTRP2 1.7654 12.4711 -1.1819 36.3844
JHH-6 GDSC1; GDSC2; CTRP2 1.9873 7.4495 1.1667 29.786
SNU-886 CTRP2 2.0057 5.302 1.8151 27.5549
SNU-878 CTRP2 2.2556 3.872 2.2471 25.2698
SNU-761 CTRP2 2.6589 9.9447 0.8597 28.6974
Huh-7 GDSC1; GDSC2 2.7595 8.6299 0.1858 18.6063
SNU-423 GDSC1; GDSC2; CTRP2 2.872 10.095 1.01 27.6143
JHH-2 GDSC1; GDSC2; CTRP2 3.0094 9.0003 1.6324 25.1563
SNU-475 CTRP2 3.1773 7.4764 2.4342 21.7838
SNU-449 GDSC1; GDSC2; CTRP2 3.285 9.0185 1.9085 23.4083
JHH-7 GDSC1; GDSC2 3.4288 8.5911 0.7759 13.7979
JHH-5 CTRP2 3.969 11.0612 1.6496 22.5242
HuH-1 GDSC1; GDSC2; CTRP2 4.165 12.3701 1.2052 23.5561
JHH-1 GDSC1; GDSC2; CTRP2 4.2544 11.2692 1.823 21.1948
JHH-4 GDSC1; GDSC2; CTRP2 4.593 12.0266 1.7717 20.5661
HLE GDSC1; GDSC2 4.7545 13.2263 -0.493 16.6797
PLC/PRF/5 CTRP2 5.0315 8.218 4.0301 10.6478
SNU-387 GDSC1; GDSC2; CTRP2 5.0991 13.9412 1.283 21.1151
SNU-398 GDSC1; GDSC2; CTRP2 5.4623 9.5611 3.7801 10.6985
Hep-G2/C3A GDSC1; GDSC2 5.631 7.6003 2.6673 0.582
HLF CTRP2 5.836 8.9336 4.4227 7.2293
SK-HEP-1 GDSC1; GDSC2; CTRP2 7.0781 14.131 2.8269 11.5119
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 222 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2171 GDSC2 -1.2556 1.0249 -1.3421 33.0972
NCI-H1648 GDSC1; GDSC2 -1.2104 2.8079 -1.4941 41.0626
EPLC-272H GDSC1; GDSC2; CTRP2 -1.2088 5.1999 -1.6577 48.5602
NCI-H1341 GDSC1; GDSC2; CTRP2 -1.0233 2.7674 -1.0797 47.161
NCI-H1975 GDSC1; GDSC2; CTRP2 -0.5455 3.6267 -0.6601 44.1411
NCI-H1184 CTRP2 -0.371 3.2466 -0.4365 42.9016
NCI-H720 GDSC1; GDSC2 -0.1679 2.8218 -0.3626 31.7732
NCI-H250 GDSC2 -0.072 4.6643 -1.2965 27.2488
HCC2935 CTRP2 0.0038 7.372 -0.9529 42.1678
NCI-H322M GDSC1; GDSC2 0.1242 6.6985 -1.4403 34.4392
Lu-134-A GDSC1; GDSC2 0.1365 5.5376 -1.4889 27.2828
A-549 GDSC1; GDSC2; CTRP2 0.2123 4.8126 -0.0313 39.5165
RERF-LC-Sq1 GDSC1; GDSC2 0.3169 5.0356 -0.5446 30.4226
HCC44 GDSC1; GDSC2; CTRP2 0.4277 5.374 0.0839 38.3789
EKVX GDSC1; GDSC2; CTRP2 0.4501 5.7412 0.0192 38.4511
NCI-H1666 GDSC1; GDSC2; CTRP2 0.6884 9.1305 -0.8596 39.3601
NCI-H69 GDSC1; GDSC2; CTRP2 0.7152 6.2969 0.1576 37.0927
NCI-H1437 GDSC1; GDSC2 0.7366 5.6225 -0.9481 22.254
NCI-H2795 GDSC1; GDSC2 0.7402 5.5726 -0.3185 27.7542
SBC-1 GDSC1; GDSC2 0.7805 4.6021 -0.4182 19.1549
NCI-H2373 GDSC1; GDSC2 0.8193 5.9431 -0.3958 27.7764
NCI-H520 GDSC1; GDSC2; CTRP2 0.8381 6.8316 0.1296 36.7053
CPC-N GDSC1; GDSC2 0.8452 7.2688 -0.9647 29.9409
NCI-H187 GDSC1 0.8648 6.1216 -1.0694 27.0074
NCI-H1703 GDSC1; GDSC2; CTRP2 0.8974 7.3987 0.0068 36.788
EMC-BAC-1 GDSC1; GDSC2 0.9232 6.2057 -1.0561 22.1351
EBC-1 GDSC1; GDSC2; CTRP2 0.9399 4.8134 0.755 34.5964
COR-L311 GDSC2 0.9417 4.3125 0.3996 23.6599
NCI-H1944 GDSC1; GDSC2; CTRP2 0.956 7.5837 0.006 36.5769
NCI-H1623 GDSC1; GDSC2; CTRP2 0.9617 6.7494 0.2901 35.8404
COR-L32 GDSC1; GDSC2 0.9626 4.7613 0.249 24.3009
NCI-H1048 GDSC1; GDSC2 1.0036 5.2349 0.0984 24.8554
NCI-H847 GDSC1; GDSC2 1.0174 5.4245 0.0326 25.1099
LC-2/ad GDSC1; GDSC2 1.0324 4.5384 -0.1443 16.6217
NCI-H1876 GDSC1; GDSC2 1.0929 6.0509 -0.1632 25.7198
NCI-H1563 GDSC1; GDSC2; CTRP2 1.0959 9.1649 -0.4413 37.0889
NCI-H446 GDSC1; GDSC2; CTRP2 1.1216 8.0288 0.0242 35.9396
DMS 273 GDSC1; GDSC2; CTRP2 1.1388 6.6322 0.5194 34.5823
DMS 114 GDSC1; GDSC2; CTRP2 1.1576 7.3503 0.3051 35.1002
EMC-BAC-2 GDSC1; GDSC2 1.2444 7.5469 -0.6995 27.4451
COR-L303 GDSC2 1.249 3.93 0.3549 12.8204
SK-MES-1 GDSC1; GDSC2; CTRP2 1.2502 7.1863 0.4613 34.3532
LXF 289 GDSC1; GDSC2; CTRP2 1.264 8.0545 0.1676 35.0839
DV-90 CTRP2 1.3326 4.0899 1.2752 31.5816
NCI-H3122 GDSC1; GDSC2 1.345 6.5598 -0.14 24.6942
NCI-H290 GDSC1; GDSC2 1.3499 4.9263 -0.0349 14.854
IST-SL2 GDSC1; GDSC2 1.4162 6.0164 0.1799 22.9492
DMS 454 CTRP2 1.4193 9.7126 -0.3246 35.7314
NCI-H835 GDSC1; GDSC2 1.4522 5.947 0.2477 22.4947
COR-L105 GDSC1; GDSC2; CTRP2 1.4744 5.8403 1.1113 31.6416
NCI-H64 GDSC1; GDSC2 1.4807 5.2387 0.5918 20.6961
NCI-H1734 GDSC2; CTRP2 1.5115 7.312 0.7013 32.7747
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2; CTRP2 1.5167 6.6113 0.9375 32.0465
Calu-3 GDSC1; GDSC2; CTRP2 1.526 6.9821 0.8288 32.3471
COR-L279 GDSC1; GDSC2 1.5373 6.3807 0.134 22.7407
NCI-H2009 GDSC1; GDSC2; CTRP2 1.6118 6.7942 0.9832 31.5874
NCI-H2122 GDSC1; GDSC2; CTRP2 1.6222 6.2088 1.1724 30.9531
COR-L23 GDSC1; GDSC2 1.7011 5.6121 0.6503 19.6235
HCC827 GDSC1; GDSC2; CTRP2 1.7414 5.7762 1.2163 25.5446
LCLC-97TM1 GDSC1; GDSC2; CTRP2 1.8253 9.8579 0.0375 33.5439
NCI-H524 GDSC1; GDSC2 1.8306 8.1752 -0.4372 24.3365
NCI-H1755 GDSC1; GDSC2; CTRP2 1.8527 8.798 0.5063 32.2085
CAL-12T GDSC1; GDSC2; CTRP2 1.8603 7.026 1.1769 30.1606
NCI-H2228 GDSC1; GDSC2; CTRP2 1.9293 10.0984 0.0423 33.2021
COLO 699 CTRP2 1.9492 8.6463 0.6694 31.4325
HCC1588 CTRP2 1.9933 5.7551 1.6988 27.9934
NCI-H2023 GDSC1; GDSC2; CTRP2 2.0426 9.5567 0.3915 31.9246
NCI-H2170 GDSC1; GDSC2; CTRP2 2.0588 4.9378 1.9393 26.9581
NCI-H1694 GDSC1; GDSC2; CTRP2 2.065 7.333 1.2922 29.1326
NCI-H292 GDSC1; GDSC2; CTRP2 2.103 9.0625 0.6617 30.9697
RERF-LC-KJ GDSC1; GDSC2 2.1056 8.9385 -0.5549 23.9493
RERF-LC-MS GDSC1; GDSC2; CTRP2 2.1163 7.7648 1.1897 29.3044
NCI-H1993 GDSC1; GDSC2 2.1376 7.4954 0.1813 20.5122
NCI-H1781 GDSC1; GDSC2 2.1461 5.2162 1.2774 14.8456
NCI-H2461 GDSC1; GDSC2 2.167 7.8209 0.0499 21.0478
NCI-H3255 GDSC1; GDSC2 2.2081 5.9181 0.2115 10.692
NCI-H2110 GDSC1; GDSC2; CTRP2 2.2083 8.3576 1.059 29.4345
NCI-H2085 GDSC1; GDSC2; CTRP2 2.217 8.2922 1.094 29.2968
SBC-3 GDSC1; GDSC2 2.2636 9.1305 -0.5055 23.246
NCI-H2066 GDSC1; GDSC2 2.3033 6.8555 0.6481 17.6558
NCI-H1793 GDSC1; GDSC2; CTRP2 2.316 9.4447 0.7233 30.1317
LB647-SCLC GDSC1; GDSC2 2.3263 5.0507 0.7374 7.0913
NCI-H2803 GDSC2 2.3272 5.4048 0.562 8.1882
NCI-H1436 GDSC1; GDSC2 2.4269 6.0247 0.3314 9.3577
NCI-H513 GDSC1; GDSC2 2.4457 7.0474 0.6866 17.0176
NCI-H1568 GDSC1; GDSC2; CTRP2 2.4472 7.3531 1.6969 26.584
NCI-H146 GDSC1; GDSC2; CTRP2 2.4852 5.9171 2.1941 24.7198
LC-1/sq GDSC1; GDSC2 2.4881 7.4573 0.524 17.725
DMS 53 GDSC1; GDSC2; CTRP2 2.5117 6.5406 2.043 25.1729
NCI-H209 GDSC1; GDSC2 2.5264 5.5089 1.5109 12.3638
NCI-H661 GDSC1; GDSC2; CTRP2 2.5383 8.6665 1.2821 27.7119
NCI-H1304 GDSC1 2.5801 5.5988 0.6582 8.6247
NCI-H2731 GDSC1; GDSC2 2.5803 8.1767 0.2518 18.8093
NCI-H2196 GDSC2; CTRP2 2.6039 6.7388 2.0795 24.7623
Lu-135 GDSC1; GDSC2 2.6118 5.9138 1.3952 12.7316
NCI-H2810 GDSC1; GDSC2 2.6236 6.0629 0.4619 8.0507
NCI-H358 GDSC1; GDSC2; CTRP2 2.6432 10.2838 0.6931 29.2462
HOP-92 GDSC1; GDSC2; CTRP2 2.652 12.9945 -0.5463 34.1835
Ms-1 GDSC1; GDSC2 2.6571 7.804 0.5053 17.3171
HCC78 GDSC1; GDSC2; CTRP2 2.6708 9.241 1.1783 27.6583
NCI-H596 GDSC1; GDSC2 2.7398 11.1068 -1.0657 24.0927
Lu-99A GDSC1; GDSC2 2.7451 10.4768 -0.7469 22.8183
NCI-H1155 GDSC1; GDSC2; CTRP2 2.7527 7.907 1.8147 25.2589
COR-L51 CTRP2 2.7862 5.8376 2.5429 22.5507
A-427 GDSC1; GDSC2 2.7896 6.9816 0.1327 9.6481
NCI-H1435 GDSC1; GDSC2; CTRP2 2.8456 7.0118 2.2485 23.4307
HCC366 GDSC1; GDSC2; CTRP2 2.8484 8.8903 1.5124 26.03
NCI-H1770 GDSC1; GDSC2 2.8557 12.9704 -2.7894 23.7202
PC-14 GDSC1; GDSC2; CTRP2 2.9334 7.3814 2.2091 23.3157
NCI-H647 GDSC1; GDSC2; CTRP2 2.9491 7.0092 2.3612 22.7154
NCI-H2869 GDSC1; GDSC2 2.9535 5.9932 0.7313 5.6418
Lu-99 CTRP2 2.9907 7.6159 2.1814 23.2498
NCI-H727 GDSC1; GDSC2; CTRP2 3.0259 8.1814 1.9938 23.8286
NCI-H345 GDSC1; GDSC2 3.0647 8.3703 -0.3473 11.7878
NCI-H1693 GDSC1; GDSC2; CTRP2 3.0652 8.2722 1.9978 23.7024
HCC95 CTRP2 3.0722 8.1371 2.0606 23.4551
LK-2 GDSC1; GDSC2 3.0851 7.9767 0.7943 14.6115
PaCa-3 GDSC1; GDSC2 3.0874 7.5141 1.0274 13.3675
NCI-H2227 GDSC1; GDSC2 3.1073 9.68 -0.9608 15.0306
HCC4006 CTRP2 3.1204 7.7739 2.2576 22.5981
HCC1438 CTRP2 3.1216 11.1662 0.7712 27.6546
HCC33 GDSC2 3.1284 7.4552 0.146 8.7656
NCI-H841 GDSC1; GDSC2; CTRP2 3.1683 9.0574 1.7716 24.2211
NCI-H1836 GDSC1; GDSC2 3.2211 6.393 0.7187 5.1671
NCI-H82 GDSC1; GDSC2 3.2756 7.6621 1.1131 12.4031
NCI-H1581 GDSC1; GDSC2; CTRP2 3.2814 7.5499 2.5168 21.1798
COR-L321 GDSC1; GDSC2 3.2848 5.066 1.359 1.5168
LOU-NH91 GDSC1; GDSC2; CTRP2 3.3032 10.6435 1.1936 25.8222
Lu-139 GDSC1; GDSC2 3.3299 7.2113 0.402 6.8123
ABC-1 GDSC1; GDSC2 3.3896 6.2641 0.8846 3.8958
NCI-H1573 GDSC1; GDSC2; CTRP2 3.3958 7.8133 2.5333 20.7955
NCI-H1395 CTRP2 3.3963 8.1119 2.4114 21.251
Lu-65 GDSC1; GDSC2; CTRP2 3.4015 6.8581 2.9031 19.3942
NCI-H1792 GDSC1; GDSC2; CTRP2 3.408 10.0572 1.5679 24.2764
NCI-H2141 GDSC1; GDSC2; CTRP2 3.466 8.5735 2.2884 21.5187
NCI-H1651 GDSC1; GDSC2; CTRP2 3.4804 6.6845 3.0485 18.6249
IST-SL1 GDSC1; GDSC2 3.483 6.39 0.8832 3.7439
NCI-H211 GDSC1; GDSC2; CTRP2 3.5564 8.114 2.5779 20.1828
NCI-H526 GDSC1; GDSC2; CTRP2 3.6317 8.7843 2.3669 20.7757
NCI-H838 GDSC1; GDSC2; CTRP2 3.6384 9.7779 1.9263 22.3889
NCI-H740 GDSC2 3.6611 6.4347 0.9662 3.0087
NCI-H1355 GDSC1; GDSC2; CTRP2 3.716 11.9792 0.9675 25.4593
NCI-H1838 GDSC1; GDSC2; CTRP2 3.7507 8.4886 2.6188 19.5011
DMS 79 GDSC1; GDSC2; CTRP2 3.7665 8.3289 2.7045 19.1308
NCI-H23 GDSC1; GDSC2; CTRP2 3.7704 9.0204 2.4032 20.2698
NCI-H2081 GDSC1; GDSC2; CTRP2 3.7763 9.185 2.335 20.5122
NCI-H2804 GDSC1; GDSC2 3.795 11.5855 -1.3916 15.5165
RERF-LC-Ad2 CTRP2 3.8036 8.797 2.5369 19.6735
NCI-H510A GDSC1; GDSC2 3.839 9.6108 -0.4034 10.3347
NCI-H2444 GDSC1; GDSC2; CTRP2 3.898 8.5569 2.7397 18.6455
UMC-11 GDSC1; GDSC2 3.909 6.7678 2.0604 5.6792
NCI-H1339 CTRP2 3.9113 8.8047 2.6429 18.9842
HOP-62 GDSC1; GDSC2; CTRP2 3.9332 11.5031 1.404 23.466
NCI-H2291 GDSC1; GDSC2; CTRP2 3.9579 13.885 0.2735 26.9338
Sq-1 CTRP2 3.9796 8.5 2.8483 18.0105
NCI-H1963 GDSC2 3.9989 8.2646 1.3896 9.1474
COLO 668 GDSC1; GDSC2; CTRP2 4.0357 9.9361 2.247 20.1744
NCI-H2818 GDSC1; GDSC2 4.0404 11.852 -0.3601 17.7528
NCI-H2135 GDSC1; GDSC2 4.119 5.6919 1.4855 0.3629
COR-L95 GDSC1; GDSC2; CTRP2 4.1401 8.8907 2.8348 17.648
HCC2108 CTRP2 4.1855 10.2723 1.6842 16.8365
HCC2279 CTRP2 4.1892 11.8173 1.4963 22.5102
LUDLU-1 CTRP2 4.2054 7.827 3.3747 15.36
NCI-H2172 GDSC1; GDSC2; CTRP2 4.2568 8.9135 2.9411 16.9338
NCI-H322 CTRP2 4.307 7.1303 3.7712 13.5441
NCI-H2722 GDSC1; GDSC2 4.3388 8.3304 1.6062 7.2557
NCI-H1105 GDSC1; GDSC2; CTRP2 4.3576 9.8876 2.584 18.0816
NCI-H2286 CTRP2 4.3593 12.1482 1.4952 22.0996
NCI-H748 GDSC2 4.3748 6.1063 1.4346 0.3792
NCI-H1650 GDSC1; GDSC2; CTRP2 4.4314 13.1738 1.0599 23.389
NCI-H2126 CTRP2 4.4315 8.8396 3.149 15.6719
NCI-H196 GDSC1; GDSC2; CTRP2 4.4544 11.1963 2.0474 19.8884
NCI-H1373 CTRP2 4.5498 11.5122 1.9831 19.8986
NCI-H2030 GDSC1; GDSC2; CTRP2 4.5888 13.0486 0.6565 19.9217
KNS-62 GDSC1; GDSC2; CTRP2 4.6082 11.1954 2.1921 18.9812
NCI-H2347 GDSC1; GDSC2 4.6307 11.6611 0.1864 13.8929
NCI-H522 GDSC1; GDSC2; CTRP2 4.7743 10.6158 2.6298 16.9077
ChaGo-K-1 GDSC1; GDSC2; CTRP2 4.8223 10.266 2.845 15.9458
NCI-H889 CTRP2 4.8355 11.6591 2.1753 18.5158
LK2 CTRP2 4.847 8.9148 3.5203 13.1646
NCI-H2595 GDSC1; GDSC2 4.849 12.5981 -0.1132 14.8049
COR-L88 GDSC1; GDSC2; CTRP2 4.8673 8.4848 3.7439 12.2078
NCI-H2106 CTRP2 4.8902 11.3734 2.3659 17.6654
NCI-H2405 GDSC1; GDSC2; CTRP2 4.9183 9.7429 3.1895 14.3401
NCI-H1299 GDSC1; GDSC2; CTRP2 4.9587 12.195 2.0232 18.8041
Calu-6 GDSC1; GDSC2; CTRP2 4.9737 9.291 3.4607 13.1091
HCC15 GDSC1; GDSC2; CTRP2 5.0292 13.9664 1.2086 21.5203
NCI-H1092 GDSC1; GDSC2; CTRP2 5.0567 10.5282 2.9342 15.0543
NCI-H226 GDSC1; GDSC2; CTRP2 5.0592 10.0734 3.1596 14.1391
MOR/CPR CTRP2 5.0634 7.3203 4.4771 8.7634
LC-1/sq-SF CTRP2 5.077 9.7466 3.336 13.3809
NCI-H650 GDSC1; GDSC2; CTRP2 5.089 10.5102 2.9727 14.8271
SW1271 GDSC1; GDSC2; CTRP2 5.1423 11.6095 2.4784 16.6643
COR-L47 CTRP2 5.2062 11.2638 2.707 15.6272
NCI-H810 GDSC1; GDSC2; CTRP2 5.2264 8.2474 4.2043 9.4728
Lu-165 GDSC1; GDSC2 5.2343 10.2926 1.2724 7.3113
NCI-H2087 GDSC1; GDSC2; CTRP2 5.2344 12.2758 2.2304 17.414
VMRC-LCD GDSC1; GDSC2; CTRP2 5.2537 11.0951 2.8332 15.0219
NCI-H1869 GDSC1; GDSC2; CTRP2 5.3239 14.6798 1.1125 21.192
HCC1833 CTRP2 5.3523 14.9936 0.9807 21.5612
NCI-H1915 GDSC1; GDSC2; CTRP2 5.552 8.9614 4.1577 8.934
NCI-H2369 GDSC1; GDSC2 5.5906 12.5015 0.4574 10.668
IA-LM GDSC1; GDSC2; CTRP2 5.6467 10.7649 3.345 12.1088
NCI-H441 GDSC1; GDSC2; CTRP2 5.6644 13.984 1.7537 18.2584
SK-LU-1 GDSC1; GDSC2; CTRP2 5.6723 16.002 0.7522 21.6118
NCI-H2342 GDSC1; GDSC2; CTRP2 5.6973 13.976 1.7857 18.0748
SHP-77 GDSC1; GDSC2; CTRP2 5.7234 9.5059 4.0394 9.0663
NCI-H2591 GDSC1; GDSC2 5.8192 15.6218 -0.8915 16.104
NCI-H2029 GDSC1; GDSC2; CTRP2 5.8617 10.4478 3.6887 10.2487
NCI-H1688 GDSC1; GDSC2 6.0277 15.0599 -0.4738 14.0048
Calu-1 CTRP2 6.0665 14.9422 1.6139 17.9368
SW1573 GDSC1; GDSC2; CTRP2 6.1511 18.6332 -0.1613 23.3232
BEN GDSC1; GDSC2; CTRP2 6.2907 7.7713 5.3767 2.3657
LCLC-103H GDSC1; GDSC2; CTRP2 6.3086 12.0755 3.2461 11.2103
RERF-LC-A1 CTRP2 6.3605 13.0047 2.8241 12.812
SBC-5 GDSC1; GDSC2; CTRP2 6.4775 13.2699 2.7859 12.7442
T3M-10 CTRP2 6.6401 8.6151 5.2152 2.4895
HCC1195 CTRP2 6.8675 18.4471 0.5149 20.0031
RERF-LC-Ad1 CTRP2 7.2827 13.387 3.347 9.1071
NCI-H460 GDSC1; GDSC2; CTRP2 8.2156 15.9979 2.7404 10.0311
HCC1171 CTRP2 10.355 21.3351 1.6237 11.0329
Hs 888.Lu CTRP2 3.2985 8.0902 2.3178 21.8723
⏷ Show the Full List of 222 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 3.157 8.9711 0.3588 16.6442
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 -1.6062 3.8414 -1.823 50.8797
Yamato-SS CTRP2 -1.2831 7.6304 -2.4355 49.1384
Rh41 GDSC1; GDSC2; CTRP2 -1.6561 1.9239 -1.6847 51.2758
Tm87-16 CTRP2 -0.9904 10.3742 -3.1331 48.0573
TTC-709 CTRP2 -0.2885 7.8102 -1.4186 44.0145
A-204 GDSC1; GDSC2; CTRP2 0.0583 7.8752 -1.0663 42.1159
STS-0421 GDSC1; GDSC2 0.0714 5.7845 -1.6685 28.3576
G-401 GDSC1; GDSC2; CTRP2 0.2125 6.5027 -0.451 40.4335
Hs 633.T GDSC1; GDSC2 0.7221 4.9902 -0.0971 26.8471
Rh30 GDSC1; GDSC2 0.8618 5.3101 -0.0812 26.2281
G-402 GDSC1; GDSC2; CTRP2 0.9122 8.9082 -0.5345 37.9312
MES-SA GDSC1; GDSC2; CTRP2 1.0322 4.8019 0.8567 33.958
TE 441.T GDSC2; CTRP2 1.1811 5.7416 0.8165 33.5642
VA-ES-BJ GDSC1; GDSC2 1.2608 6.0843 -0.0076 24.3918
KYM-1 GDSC1; GDSC2; CTRP2 1.2713 5.4214 0.9913 32.7108
Rh18 GDSC1; CTRP2 1.5828 8.186 0.4596 33.2232
EW-8 GDSC1; GDSC2 1.9155 4.7017 1.2731 15.6585
MFH-ino GDSC1; GDSC2 2.0727 7.9922 -0.1215 22.1466
RD GDSC1; GDSC2; CTRP2 2.4533 8.2802 1.3493 27.7454
SW872 GDSC1; GDSC2 2.7421 9.2763 -0.1513 20.2465
TE 617.T CTRP2 2.8429 5.8611 2.5988 22.1762
SK-LMS-1 GDSC1; GDSC2; CTRP2 2.9632 9.0534 1.5617 25.5319
SW684 GDSC1; GDSC2 2.9669 10.5388 -0.5865 21.523
BT-16 CTRP2 3.2109 11.1049 0.8881 27.05
SW982 GDSC1; GDSC2; CTRP2 3.5056 12.6521 0.4433 27.597
GCT GDSC1; GDSC2; CTRP2 4.1441 12.0144 1.3582 23.0944
Hs 729.T CTRP2 4.5691 9.7045 2.8756 16.4227
SK-UT-1 GDSC1; GDSC2; CTRP2 5.3055 15.2702 0.8022 22.2321
RKN GDSC1; GDSC2; CTRP2 5.7033 10.7259 3.4136 11.7096
HT-1080 GDSC1; GDSC2; CTRP2 5.7188 9.2196 4.1779 8.4965
BT-12 CTRP2 7.557 8.5496 5.7234 0.104
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 -1.1704 9.8247 -3.1085 48.7718
IGROV-1 GDSC1; GDSC2; CTRP2 -1.4011 3.963 -1.6221 49.6383
A2780 GDSC1; GDSC2; CTRP2 -1.3181 4.9512 -1.7206 49.178
COV434 CTRP2 0.4368 4.2843 0.2998 37.7697
OVK18 GDSC1; GDSC2; CTRP2 0.6814 5.1365 0.4121 36.5404
SNU-840 CTRP2 0.6934 9.9872 -1.1996 39.9196
OVTOKO GDSC1; GDSC2; CTRP2 0.7323 8.3583 -0.516 38.5471
OC 314 GDSC1; GDSC2; CTRP2 1.0216 6.3771 0.4686 35.1414
FU-OV-1 GDSC1; GDSC2; CTRP2 1.4163 8.323 0.2293 34.4017
DOV13 GDSC1; GDSC2; CTRP2 1.6147 8.8536 0.2324 33.7283
JHOS-4 GDSC1; GDSC2 1.8394 5.5735 0.0777 12.5929
ONCO-DG-1 CTRP2 1.9739 9.256 0.4461 31.9899
MCAS CTRP2 2.3321 6.1741 1.9569 26.0304
COV644 CTRP2 2.3376 8.0906 1.3014 28.2552
JHOM-1 CTRP2 2.3859 7.7046 1.5012 27.4408
OVCAR-3 GDSC1; GDSC2 2.5874 9.3818 -0.34 21.5481
OAW42 GDSC1; GDSC2; CTRP2 2.7211 9.3847 1.1685 27.5429
SNU-8 CTRP2 2.7881 8.7673 1.5016 26.2413
OVCAR-5 GDSC1; GDSC2; CTRP2 2.8543 12.1817 0.0339 30.4855
Caov-4 GDSC1; GDSC2 3.1811 6.9156 1.4064 11.0535
RMG-I GDSC1; GDSC2; CTRP2 3.2325 11.9649 0.5062 28.1402
SNU-119 CTRP2 3.2485 7.9496 2.3228 21.9941
SK-OV-3 GDSC1; GDSC2; CTRP2 3.2762 10.5643 1.2033 25.8643
OV7 CTRP2 3.2837 9.3075 1.78 23.8712
OAW28 GDSC1; GDSC2; CTRP2 3.3894 10.1908 1.4881 24.6015
EFO-27 GDSC1; GDSC2; CTRP2 3.5261 8.9945 2.1662 21.8093
ES-2 GDSC1; GDSC2 4.04 7.1931 1.9473 6.0225
Caov-3 GDSC2; CTRP2 4.0511 10.1107 2.1801 20.3864
TYK-nu GDSC1; GDSC2; CTRP2 4.1345 10.7983 1.9347 21.0854
OVISE GDSC1; GDSC2; CTRP2 4.2145 13.9684 0.4702 25.7379
TOV-112D GDSC1; GDSC2; CTRP2 4.3095 11.1356 1.9398 20.6354
JHOC-5 CTRP2 4.5559 9.0534 3.1716 15.2746
OVCAR-4 GDSC1; GDSC2; CTRP2 4.7875 10.7476 2.5778 17.0806
TOV-21G GDSC1; GDSC2; CTRP2 5.0346 10.3845 2.9844 14.9022
JHOS-2 GDSC1; GDSC2; CTRP2 5.1772 13.1209 1.7598 19.2794
OV56 GDSC1; GDSC2; CTRP2 5.2012 10.2118 3.2221 13.5672
COV362 CTRP2 5.2447 10.0765 3.3285 13.0366
OVSAHO CTRP2 5.2753 12.533 2.1388 17.671
HEY A8 CTRP2 5.3801 12.5864 2.2045 17.1964
OVKATE GDSC1; GDSC2 5.4684 13.3328 -0.0271 13.1419
Kuramochi GDSC1; GDSC2; CTRP2 5.7753 14.7145 1.4831 18.9842
OVCAR-8 GDSC1; GDSC2; CTRP2 5.7839 14.0601 1.8175 17.7814
EFO-21 GDSC1; GDSC2; CTRP2 5.9167 13.5031 2.2081 16.0665
OV-90 GDSC1; GDSC2; CTRP2 7.1824 16.6248 1.6701 15.6436
ES2 CTRP2 7.6198 12.9811 3.785 6.8345
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 2.0931 5.8996 1.7709 27.4278
P-STS CTRP2 6.1344 7.5577 5.3614 2.702
SYO-1 CTRP2 9.71 28.0903 -2.0929 22.0681
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 2.2572 5.7967 1.9763 26.1973
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC1; GDSC2; CTRP2 0.989 6.4561 0.4096 35.4215
NCI-H28 GDSC1; GDSC2; CTRP2 2.7133 9.3107 1.1923 27.4886
IST-Mes1 GDSC1; GDSC2; CTRP2 3.0688 9.3624 1.5359 25.3214
NCI-H2452 GDSC1; GDSC2; CTRP2 3.4577 10.6812 1.3293 24.9561
NCI-H2052 GDSC1; GDSC2; CTRP2 4.2929 12.1979 1.4089 22.5572
MPP 89 GDSC1; GDSC2; CTRP2 4.3916 11.1264 2.022 20.1337
ACC-MESO-1 CTRP2 4.5438 11.767 1.8531 20.3883
JL-1 CTRP2 8.8867 34.3992 -5.8396 29.67
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1; GDSC2; CTRP2 -0.253 4.9702 -0.5675 42.6363
22Rv1 GDSC1; GDSC2; CTRP2 1.2782 7.2549 0.4684 34.2361
VCaP GDSC1; GDSC2; CTRP2 2.0369 5.7783 1.7406 27.7109
PC-3 GDSC1; GDSC2 2.4101 9.3769 -0.4954 22.7547
NCI-H660 GDSC2; CTRP2 2.8359 7.8009 1.9447 24.5539
PaCa-3 CTRP2 4.0434 8.481 2.9217 17.5583
DU145 GDSC1; GDSC2; CTRP2 5.9672 13.6466 2.1788 16.0756
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 -0.3871 3.1977 -0.4492 43
A-253 GDSC1; GDSC2 5.1983 10.1486 1.317 7.1489
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 0.1923 5.0666 -1.2145 25.7438
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-216 CTRP2 -2.5566 2.8374 -2.7001 56.6263
HGC-27 GDSC1; GDSC2; CTRP2 -2.2075 1.5603 -2.2352 54.848
NCI-N87 GDSC1; GDSC2; CTRP2 -0.6887 7.3333 -1.6921 46.0304
HSC-39 GDSC1; GDSC2 -0.6063 2.3283 -0.7404 35.3641
GCIY GDSC1; GDSC2 -0.474 3.9865 -1.0195 35.7656
TMK-1 GDSC1; GDSC2 -0.3342 3.4117 -1.0352 27.1065
23132/87 GDSC1; GDSC2; CTRP2 -0.2691 4.5692 -0.5063 42.5929
AGS GDSC1; GDSC2; CTRP2 0.1703 3.9644 0.0589 39.4532
NCC-StC-K140 CTRP2 0.3033 3.6802 0.2316 38.465
Fu97 GDSC1; GDSC2; CTRP2 0.4614 5.0485 0.1917 37.9708
SNU-601 CTRP2 0.5237 10.644 -1.6504 41.1886
SNU-5 GDSC1; GDSC2; CTRP2 0.5458 5.6113 0.1561 37.7392
ECC10 GDSC1; GDSC2; CTRP2 0.6528 5.808 0.2232 37.1588
SK-GT-2 GDSC1; GDSC2 1.1639 5.2775 0.2473 23.5461
SNU-620 CTRP2 1.392 5.9151 1.0018 32.2669
IM95 GDSC1; GDSC2; CTRP2 1.418 6.8931 0.7406 32.9759
NUGC-3 GDSC1; GDSC2; CTRP2 1.4265 6.4289 0.8947 32.4824
GSS CTRP2 1.4412 5.7192 1.1058 31.7708
RERF-GC-1B GDSC1; GDSC2 1.5816 7.7531 -0.4704 25.3159
Hs 746.T GDSC1; GDSC2; CTRP2 1.7983 7.8859 0.8035 31.5223
MKN1 GDSC1; GDSC2; CTRP2 1.9414 8.0575 0.8918 30.7936
SCH GDSC1; GDSC2 2.2025 7.9481 -0.807 16.6607
SNU-16 GDSC1; GDSC2; CTRP2 2.4882 5.2936 2.3396 24.2004
RF-48 GDSC1; GDSC2 2.6316 8.1491 0.3114 18.3642
SNU-1 GDSC1; GDSC2; CTRP2 2.7107 6.2578 2.3458 23.4856
NUGC-4 GDSC1; GDSC2; CTRP2 2.8381 8.7132 1.5765 25.8404
SNU-668 CTRP2 3.2064 7.904 2.2967 22.2094
TGBC11TKB GDSC1; GDSC2 3.2767 7.5208 1.1847 12.0129
SNU-719 CTRP2 3.6245 11.5784 1.0704 25.3669
MKN74 CTRP2 3.6339 12.3744 0.6994 26.5041
HuG1-N CTRP2 3.6845 11.0828 1.3636 24.2421
KE-39 CTRP2 4.1578 12.7319 1.0224 24.1717
OCUM-1 GDSC1; GDSC2; CTRP2 4.1949 8.2755 3.1676 16.2007
MKN28 GDSC1; GDSC2 4.2276 11.1971 0.1113 15.1575
LMSU CTRP2 4.8889 12.6944 1.7133 20.0911
KATO III GDSC1; GDSC2; CTRP2 5.0747 10.3362 3.0451 14.5674
ECC12 GDSC2; CTRP2 5.3533 13.3836 1.784 18.8086
MKN7 GDSC1; GDSC2; CTRP2 5.8074 13.7773 1.9788 17.1442
GSU CTRP2 6.0248 7.9276 5.0864 4.0648
SH-10-TC CTRP2 6.9364 14.141 2.7134 12.2013
MKN45 GDSC1; GDSC2; CTRP2 7.4127 18.4947 0.9195 17.7597
SNG-M GDSC1; GDSC2; CTRP2 3.2937 8.6348 2.0837 22.7484
SNU-1077 CTRP2 4.305 8.569 3.147 15.9987
SNU-685 CTRP2 5.8464 10.4777 3.6607 10.3959
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
K5 GDSC1; GDSC2 0.0859 4.6495 -0.644 31.8091
ASH-3 GDSC1; GDSC2 1.3061 6.1151 0.0243 24.0793
KMH-2 GDSC1; GDSC2 1.6683 4.5923 0.418 11.0152
IHH-4 GDSC1; GDSC2 1.7137 5.9509 0.508 20.2985
8305C GDSC1; GDSC2; CTRP2 1.8864 9.9329 0.069 33.2699
BHT-101 GDSC1; GDSC2; CTRP2 2.1718 8.6036 0.9218 29.9753
CAL-62 GDSC1; GDSC2; CTRP2 2.2286 7.7031 1.3332 28.4856
SW579 CTRP2 2.2995 7.9999 1.2961 28.3891
TT GDSC1; GDSC2; CTRP2 2.5676 6.0973 2.2355 24.3179
HTC-C3 GDSC1; GDSC2 2.7668 10.883 -0.9306 23.492
WRO GDSC1; GDSC2 3.3863 10.071 0.0009 17.7612
CGTH-W-1 GDSC1; GDSC2; CTRP2 3.5819 8.7111 2.348 20.9808
FTC-238 CTRP2 3.9815 8.6951 2.7632 18.3361
B-CPAP GDSC1; GDSC2; CTRP2 4.6991 11.2062 2.2715 18.4672
8505C GDSC1; GDSC2; CTRP2 4.8962 10.9124 2.5979 16.7516
TT2609-C02 GDSC1; GDSC2; CTRP2 5.2306 11.6801 2.5226 16.2984
ML-1 [Human leukemia] GDSC1; GDSC2; CTRP2 5.54 11.3505 2.9601 13.899
FTC-133 GDSC1; GDSC2; CTRP2 6.7353 13.7983 2.7272 12.5045
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-10B CTRP2 -1.8007 2.7625 -1.8937 52.146
DOK GDSC1; GDSC2 -1.7747 2.0998 -1.9605 45.54
BB49-HNC GDSC1; GDSC2 -1.5764 2.8052 -1.8921 44.1485
NCI-H3118 GDSC1; GDSC2 -1.0238 4.1743 -1.6781 40.5143
BICR 56 CTRP2 -0.5932 5.4172 -1.0382 44.9289
SCC-25 GDSC1; GDSC2; CTRP2 -0.4873 4.1773 -0.6746 43.8943
PCI-04B GDSC1; GDSC2 -0.3209 3.0928 -0.8971 26.3344
BICR 10 GDSC1; GDSC2 -0.2896 4.6091 -1.0332 34.943
HO-1-u-1 GDSC1; GDSC2 -0.2466 2.3588 -0.3582 32.1069
CAL-33 GDSC1; GDSC2; CTRP2 -0.1686 3.6609 -0.2646 41.6415
SNU-1076 CTRP2 -0.1658 5.2351 -0.5304 42.1826
JHU-011 GDSC1; GDSC2 -0.1566 3.6986 -0.9649 25.9558
KON GDSC1; GDSC2 -0.1469 3.4559 -0.8549 25.3377
SAT [Human HNSCC] GDSC1; GDSC2 0.0073 6.724 -1.5718 35.3299
JHU-022 GDSC1; GDSC2 0.0878 4.527 -0.597 31.6135
HSC-2 GDSC1; GDSC2; CTRP2 0.2861 3.5065 0.2296 38.5351
JHU-029 GDSC1; GDSC2 0.3893 3.0247 -0.1146 18.9444
SNU-1214 CTRP2 0.4296 5.6346 0.0236 38.5207
HO-1-N-1 GDSC1; GDSC2 0.4505 4.478 -0.189 28.3552
BB30-HNC GDSC1; GDSC2 0.4522 4.0073 -0.4701 20.7217
OSC-19 GDSC1; GDSC2 0.7007 4.9157 -0.6443 20.7373
SAS GDSC1; GDSC2 0.9753 5.014 0.1604 24.6719
PCI-06A GDSC1; GDSC2 1.1143 5.2726 -0.4225 17.967
PCI-38 GDSC1 1.151 5.9462 -0.7187 23.7166
BHY GDSC1; GDSC2; CTRP2 1.3116 4.8067 1.157 32.0415
HSC-3 GDSC1; GDSC2; CTRP2 1.3211 6.5199 0.7524 33.2727
Detroit 562 GDSC1; GDSC2; CTRP2 1.4267 5.0787 1.232 31.4099
Ca9-22 GDSC1; GDSC2 1.5928 5.3726 0.6479 20.0145
BICR 22 GDSC1; GDSC2; CTRP2 1.5967 6.652 1.012 31.5475
KOSC-2 GDSC1; GDSC2 1.6357 5.4963 -0.0603 14.0692
SCC-9 GDSC1; GDSC2; CTRP2 1.6886 7.9911 0.6466 32.3433
BICR 31 GDSC2; CTRP2 1.6984 5.7897 1.3685 30.061
SCC-15 GDSC1; GDSC2 1.7515 6.7119 0.1895 21.7382
PE/CA-PJ34 (clone C12) CTRP2 1.7628 5.1785 1.5765 29.1535
OSC-20 GDSC1; GDSC2 1.9168 8.8213 -0.6715 25.038
BICR 18 CTRP2 2.0816 5.8965 1.7592 27.5044
CAL-27 GDSC1; GDSC2; CTRP2 2.1673 7.4115 1.3744 28.5401
PCI-15A GDSC1; GDSC2 2.1772 3.9023 1.1922 4.6221
BICR 78 GDSC1; GDSC2 2.3 9.2637 -0.5384 23.2738
YD-8 CTRP2 2.3011 7.8362 1.3606 28.1715
PE/CA-PJ49 CTRP2 2.3438 7.1557 1.6558 27.042
BICR 16 CTRP2 2.3706 7.7854 1.4542 27.646
PE/CA-PJ15 GDSC1; GDSC2; CTRP2 2.4442 6.5349 1.9712 25.6334
SCC-4 GDSC1; GDSC2; CTRP2 2.4526 7.4442 1.6695 26.6622
HSC-4 GDSC1; GDSC2; CTRP2 2.5412 7.9356 1.5785 26.7081
SKN-3 GDSC1; GDSC2 2.601 7.6431 0.5346 17.3332
SNU-46 CTRP2 2.6591 15.7261 -1.843 35.0759
LB771-HNC GDSC1; GDSC2 2.7064 7.375 0.7621 15.8483
SNU-899 CTRP2 2.7306 7.427 1.9746 24.7572
PCI-30 GDSC1; GDSC2 2.7531 8.3488 0.32 17.9672
SNU-1066 CTRP2 3.2089 8.3337 2.1229 22.8416
UPCI-SCC-090 GDSC1; GDSC2 3.6267 9.0175 0.7239 13.567
BICR 6 CTRP2 3.8029 15.8676 -0.8409 30.1682
PE/CA-PJ41 (clone D2) CTRP2 4.2464 8.9029 2.9356 16.9821
SNU-1041 CTRP2 4.5961 10.5158 2.5109 17.79
FaDu GDSC1; GDSC2; CTRP2 4.6617 14.7685 0.4825 24.6478
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-BLC1 CTRP2 -1.6915 3.2963 -1.8371 51.4289
CAL-29 GDSC1; GDSC2; CTRP2 -0.1113 3.7338 -0.2122 41.2772
VM-CUB-1 CTRP2 1.1642 4.8363 0.993 33.0716
JMSU-1 CTRP2 1.2893 6.8447 0.6163 33.7808
KMBC-2 CTRP2 1.5832 7.6276 0.6672 32.6333
BC-3C CTRP2 1.6023 5.3149 1.3745 30.3568
SW1710 GDSC1; GDSC2; CTRP2 1.6193 7.3454 0.8063 32.1027
SCaBER CTRP2 1.7159 7.9596 0.6876 32.1346
UM-UC-3 GDSC1; GDSC2; CTRP2 1.7776 6.3486 1.3014 30.0238
5637 GDSC1; GDSC2; CTRP2 1.9221 6.7169 1.3455 29.4117
253J-BV CTRP2 2.0419 5.3791 1.8384 27.3587
BFTC-905 GDSC1; GDSC2; CTRP2 2.3957 7.694 1.5156 27.3621
RT-112 GDSC1; GDSC2; CTRP2 2.8391 8.976 1.4663 26.2138
647V GDSC1; GDSC2; CTRP2 2.9155 7.9062 1.9879 24.1675
SW780 GDSC1; GDSC2 3.12 9.0046 0.3106 16.9835
HT-1197 GDSC1; GDSC2; CTRP2 3.1373 9.8007 1.4111 25.5552
TCCSUP GDSC1; GDSC2; CTRP2 3.6635 9.6665 2.0025 22.0452
RT-4 GDSC1; GDSC2; CTRP2 4.0779 7.6168 3.3311 15.871
HT-1376 GDSC1; GDSC2; CTRP2 5.158 12.6644 1.9695 18.5581
J82 GDSC1; GDSC2; CTRP2 5.5616 13.6424 1.8359 18.1771
T24 GDSC1; GDSC2; CTRP2 5.7625 11.3681 3.1442 12.693
UM-UC-1 CTRP2 5.9252 92.1862 -37.1259 45.3246
KU-19-19 GDSC1; GDSC2; CTRP2 8.7385 18.915 1.6926 13.0329
639V GDSC1; GDSC2; CTRP2 9.9898 20.8376 1.6209 11.515
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BPH-1 GDSC1; GDSC2 -1.0077 4.2139 -1.6737 40.4183
ACC-OV7 GDSC1; GDSC2 -0.6309 5.8947 -2.4171 34.2704
CAL-39 GDSC1; GDSC2 -0.5979 3.137 -0.9069 35.9634
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 -0.2128 2.1898 -0.4692 23.5584
PA-1 GDSC1; GDSC2 0.1667 4.2093 -0.399 30.4573
OVCA420 GDSC1; GDSC2 0.25 5.2922 -0.7175 31.3919
OVCA433 GDSC1; GDSC2 0.2832 5.8998 -1.5163 26.8165
NEC8 GDSC1; GDSC2 0.666 5.2487 -0.2612 27.7987
ME-180 GDSC1; GDSC2 0.7051 5.6783 -0.3999 28.2407
OVMIU GDSC1; GDSC2 0.8889 5.65 -0.1971 26.6438
Ca Ski GDSC1; GDSC2 0.8958 5.4226 -0.093 26.1502
UWB1.289 GDSC1; GDSC2 1.0195 6.1672 -0.9481 21.2241
KGN GDSC1; GDSC2 1.2825 6.9017 -0.3602 25.8936
TC-YIK GDSC1; GDSC2 1.2898 6.0116 0.0544 23.9978
SKN GDSC1; GDSC2 1.3553 7.4516 -0.5462 26.4231
JHOS-3 GDSC1; GDSC2 1.5047 4.8003 0.1684 13.0948
SW954 GDSC1; GDSC2 1.5381 3.9323 0.6262 10.1395
NT2-D1 GDSC1; GDSC2 1.5654 6.4252 0.1411 22.6087
NCC-IT GDSC2 1.6255 6.855 -0.001 23.0712
C-4-I GDSC1; GDSC2 1.7024 7.9007 -0.4258 24.7152
SW962 GDSC1; GDSC2 1.8738 7.9175 -1.0646 19.0119
HEY GDSC1; GDSC2 1.9318 7.5426 -0.0352 22.2036
OV17R GDSC1; GDSC2 2 10.261 -2.1305 23.5776
C-33 A GDSC1; GDSC2 2.0712 5.1062 1.2527 15.2279
DSH1 GDSC1; GDSC2 2.2348 6.8843 0.5697 18.2724
SKG-IIIa GDSC1; GDSC2 2.3454 7.2017 0.5183 18.1895
JAR GDSC1; GDSC2 2.5878 5.4566 0.7337 6.4577
PWR-1E GDSC1; GDSC2 2.5947 8.9674 -0.1276 20.5691
SiSo GDSC1; GDSC2 2.6314 8.2777 0.2474 18.6792
JEG-3 GDSC1; GDSC2 2.6961 6.2828 0.4074 8.2074
HT-3 GDSC1; GDSC2 3.0562 7.9491 0.7834 14.7479
LB831-BLC GDSC1; GDSC2 3.1209 9.3521 0.1377 17.8231
HEC-1 GDSC1; GDSC2 3.9202 9.666 0.6337 13.3152
PEO1 GDSC1; GDSC2 3.9434 11.0651 -0.0447 16.564
MS751 GDSC1; GDSC2 4.5374 11.512 0.1905 14.079
SiHa GDSC1; GDSC2 4.6105 11.4074 0.2964 13.4125
DoTc2 4510 GDSC1; GDSC2 4.6661 8.7498 1.63 6.4949
SW756 GDSC1; GDSC2 5.3849 12.9279 0.1106 12.6801
HeLa GDSC1; GDSC2; CTRP2 7.1971 17.7707 1.112 17.516
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 Phase II Randomized Preoperative Window-of-Opportunity Study of the PI3K Inhibitor Pictilisib Plus Anastrozole Compared With Anastrozole Alone in P... J Clin Oncol. 2016 Jun 10;34(17):1987-94.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5682).
3 Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009 Aug;8(8):627-44.
4 The novel dual PI3K/mTOR inhibitor GDC-0941 synergizes with the MEK inhibitor U0126 in non-small cell lung cancer cells. Mol Med Rep. 2012 Feb;5(2):503-8. doi: 10.3892/mmr.2011.682. Epub 2011 Nov 16.
5 Phosphoinositide 3-kinase (PI3K) pathway alterations are associated with histologic subtypes and are predictive of sensitivity to PI3K inhibitors in lung cancer preclinical models. Clin Cancer Res. 2012 Dec 15;18(24):6771-83. doi: 10.1158/1078-0432.CCR-12-2347. Epub 2012 Nov 7.
6 Role of P-glycoprotein and breast cancer resistance protein-1 in the brain penetration and brain pharmacodynamic activity of the novel phosphatidylinositol 3-kinase inhibitor GDC-0941. Drug Metab Dispos. 2010 Sep;38(9):1422-6. doi: 10.1124/dmd.110.034256. Epub 2010 Jun 3.
7 Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res. 2012 Jan 1;72(1):210-9. doi: 10.1158/0008-5472.CAN-11-1515. Epub 2011 Nov 14.
8 Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition. Cancer Lett. 2011 Jan 28;300(2):145-53. doi: 10.1016/j.canlet.2010.09.016. Epub 2010 Nov 3.
9 A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicol Sci. 2013 Nov;136(1):216-41.
10 GDC-0941 inhibits metastatic characteristics of thyroid carcinomas by targeting both the phosphoinositide-3 kinase (PI3K) and hypoxia-inducible factor-1 (HIF-1) pathways. J Clin Endocrinol Metab. 2011 Dec;96(12):E1934-43. doi: 10.1210/jc.2011-1426. Epub 2011 Oct 12.
11 PI3K inhibition enhances doxorubicin-induced apoptosis in sarcoma cells. PLoS One. 2012;7(12):e52898. doi: 10.1371/journal.pone.0052898. Epub 2012 Dec 31.
12 The PI3K inhibitor GDC-0941 combines with existing clinical regimens for superior activity in multiple myeloma. Oncogene. 2014 Jan 16;33(3):316-25. doi: 10.1038/onc.2012.594. Epub 2013 Jan 14.
13 GDC-0941 enhances the lysosomal compartment via TFEB and primes glioblastoma cells to lysosomal membrane permeabilization and cell death. Cancer Lett. 2013 Feb 1;329(1):27-36. doi: 10.1016/j.canlet.2012.09.007. Epub 2012 Sep 18.